was used to phase heterozygous SNPs and to re-estimate allele-specific copy number. In addition, mirrored subclonal allelic imbalance3, which results from SCNAs that disrupt the same genomic region but affect different parental alleles within separate tumour subclones, was detected as previously desc...
Revealing the genetic architecture of the cranial vault is a necessary step toward elucidating the various molecular pathways involved in both normal and abnormal cranial development and growth. However, despite evidence of a genetic contribution, we know little about the specific genes that impact vari...
Advantages of transcriptomics –mutation frequency and allele variant detection now at 80% (higher sensitivity in mutation detection) –transcriptomics has good detection of chromosomal translocations –great surrogate for IHC and detect splicing alterations –can use AI to predict % of PDL1 in tumor c...
Any behavioral propensity (e.g mutant allele) that entails self-complacency to mating failure/sexual ostracism will be purged/culled by selection (i.e. maladaptive trend) , since the genes that induce such behavior/conformity will not be replicated in future generations. Men Going Their Own Way ...
Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In the mouse, it...
Horizontal Gene Transfer (HGT) is beneficial to a cell if the acquired gene confers a useful function, but is detrimental if the gene has no function, if it is incompatible with existing genes, or if it is a selfishly replicating mobile element. If the b
we analyzed the response to light of homozygous mutant larvae carrying a putative null allele of theTRHlocus (referred to aspBacTRH). These mutant larvae are viable and show diminished 5-HT staining in the CNS [39]. Consistent with our previous observations,pBacTRHmutant larvae present an incr...
94 isolates we studied none carried the Y136F allele as a single copy gene. However, we did not observe any obvious impact of the Y136F mutation on fungal growth when growth rates of wild type and mutant strains in the absence of fungicide were compared (Additional file16: Figure S6A)....
a number of simulation studies have demonstrated that allele frequency clines can also occur in range expansions where admixture is not present.16 – 19 The impact of the Neolithic in the Balkans, as archaeological records show, is regarded to be considerable,20 although Mesolithic hunter-gatherers...
allele frequency of long-grain and slender-grain alleles from wild to landrace and from landrace to cultivar.jAverage grain length, grain width and the length-width ratio of the landraces and cultivars. Data are presented as mean ± SD.nshows the biologically independent samples.kNucleotide ...