Any of the possible forms in which a gene for a specific trait can occur. In almost all animal cells, two alleles for each trait are inherited, one from each parent. Alleles on each of a pair of chromosomes are called homozygous if they are similar to each other and heterozygous if they...
The effect is milder in single inhibitor treatments. d, Heat map and box plots of differentially expressed genes during DNMT1i (left) and long-term EZH2i (right) treatment including recovery timepoints (number of genes indicated in the figure, differentially expressed genes are identical to ...
This allele has been previously associated with increased skipping of exon 687. Full size image As expected, the number of sGenes over the number of tested genes grows with the tissue sample size (r2 = 0.91). This is explained by the gain of power to detect sQTLs as the number of...
Because of the relative homogeneity of the Afrikaner population, it had been assumed that individuals affected with sclerosteosis shared a common disease allele. We therefore used the approach of homozygosity mapping (Lander and Botstein 1987) to identify and refine the sclerosteosis locus in aff...
Answer to: Answer true or false: (a) Each homologous pair is made of chromosomes of the same length. (b) Homologous pairs are present in haploid...
Portion (0.0-1.0) of read pairs to be considered concordant. Concordant read pairs are considered to provide no support for structural variation. Clearing this value will cause GRIDSS to use the 0x02 proper pair SAM flag written by the aligner to determine concordant pairing. Note that some ali...
The rmsd of all backbone atoms is less than 1.0 Å; the rmsd of side chain atoms in the DNA interface is ∼1.7 Å. Accommodation of differences in DNA base pair recognition by the two subunits, leading to binding and cleavage of the asymmetric target site, is almost entirely ...
Pollinator-driven evolution of floral traits is thought to be a major driver of angiosperm speciation and diversification. Ophrys orchids mimic female insects to lure male pollinators into pseudocopulation. This strategy, called sexual deception, is spec
c Effect plot for the peak locus on chromosome 5 at 23.3 Mb, the genotypes (X-axis) of which explain 48.2% of the observed phenotypic variance (i.e., narrow-sense heritability, h2), suggests that an increased dose of the ‘A’ allele is associated with lower severity of YAD. ...
The laboratory mouse was domesticated from the wild house mouse. Understanding the genetics underlying domestication in laboratory mice, especially in the widely used classical inbred mice, is vital for studies using mouse models. However, the genetic me