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Responses to two identical questions (“Are you naturally a night person or a morning person?”) were used to define the dichotomous morning person phenotype in the 23andMe cohort, with one question having a wider selection of neutral options. For the first instance, the possible answers were ...
Whole genome sequence (WGS) data could transform our ability to attribute individuals to source populations. However, methods that efficiently mine these data are yet to be developed. We present a minimal multilocus distance (MMD) method which rapidly de
Eight individuals unidentifiable to the species level collected in the river between 2017 and 2018 were examined and compared with the Tango and Ohshima loach species. Using mitochondrial DNA (mtDNA) cytochrome b analysis, we found that six individuals had mtDNA types identical to Tango loach and ...
Despite differences in taxon (two birds, one mammal, one insect), population size, number of loci and polymorphism across loci, the degree of differences between simulated and empirical dataset allele frequencies, expected heterozygosities and pairwise FST values were almost identical among the four...
Forty-two sequence variants that are likely to represent neutral polymorphisms were observed in subjects with CdLS, unaffected family members, and/or control individuals (table 3). Three of the polymorphisms (N674S, N1994S, and I1206V) in the coding region of NIPBL led to an altered amino...
As shown in Fig 3, fragments of S–s–U– DNA digested with EcoRI and PstI are identical to those of the DNA of control individuals except for the weaker intensity of the smallest size bands; this was also observed in control and variant DNA patterns with Kpn I digests (gels not show...
We return to the issue of how many SNPs are appropriate for analysis with CrypticIBDcheck in the Conclusions section. The relatedness between two individuals may be defined in terms of the proportion of loci at which they share zero, one or two alleles that are identical-by-descent (IBD). ...
For generality, relatedness estimators are described for a locus with any number of alleles and for multiple loci. For simplicity, however, the bias of the estimators is investigated by considering a single locus with two codominant alleles, A and B, with frequencies p and q ( = 1 − p)...
the presence of ancestry-specific alleles that are nearly monoallelic in individuals of European ancestry increases the power to detect novel metabolomic associations with established cardiovascular risk loci—and represents an important first step in the broader discovery of ancestry-specific, pathogenically...