Sex differences in the fitness effects of alleles at a single locus (intralocus sexual antagonism, or SA) have several evolutionary consequences. Among the consequences of SA, polymorphisms at genes partially linked to the sex-determining region of the sex chromosome pair potentially drive the evolut...
Psychiatric disorders are highly genetically correlated, but little research has been conducted on the genetic differences between disorders. We developed a new method (case–case genome-wide association study; CC-GWAS) to test for differences in allele frequency between cases of two disorders using ...
Duplicated loci, for example those associated with major histocompatibility complex (MHC) genes, often have similar DNA sequences that can be coamplified with a pair of primers. This results in genotyping difficulties and inaccurate analyses. Here, we present a method to assign alleles to ...
A standard competition ELISA was used to address whether the antibody response can be further focused on shared epitopes by exclusively boosting these common determinants through immunization of rabbits with different Pf AMA1 alleles in sequence. The in vitro parasite growth inhibition assay was used ...
In humans, the inheritance of sickle-cell anemia/trait is determined by a single pair of alleles that exhibit incomplete dominance. Individuals homozygous for the sickling gene (s) have ''sickle-cell anemia''. In ss, the sickling gene causes ...
The expression patterns of the two fly MMPs are very different, and genetic analysis with over a dozen MMP alleles, including conditional temperature-sensitive alleles, has demonstrated some distinct and some shared functions for each MMP. For example, Mmp1 is required for tube elongation and ...
How many autosomal chromosomes are in a normal human gamete? How are somatic and germline mutations different? What is the difference between genes, chromosomes, and DNA? What is different between two alleles of the same gene? Do female and male autosomal chromosomes have the same alleles? What...
The mean value of number on alleles(Na) of CSC, AQC, JXC, JJC, SSC, SJC, RCC, HJC and HC was 4.67, 5.22, 5.33, 5.00, 4.89, 4.78, 4.89, 4.67 and 2.56, respectively. The mean value of expected heterozygosity(He) was 0.6397, 0.6543, 0.6831, 0.6356, 0.6737, 0.6483, 0.6664, 0.7129...
Under a Creative Commons license open accessHighlights Abstract Polymorphic alleles of the human dopamine D4 receptor gene (DRD4) have been consistently associated with individual differences in personality traits and neuropsychiatric disorders, particularly between the gene encoding dopamine D4.7 receptor var...
The choice in meiosis – defining the factors that influence crossover or non-crossover formation Meiotic crossovers are essential for ensuring correct chromosome segregation as well as for creating new combinations of alleles for natural selection to t... JL Youds,SJ Boulton - 《Journal of Cell...