别名Apoptosis Related Protein TGFb Signalling; Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; bradeion; Bradeion beta; Brain protein H5; CE5B3; CE5B3 beta; cell division control-related protein 2; cerebral protein 7; H5 antibody hCDCREL-2; hucep-7; peanut-like 2; Peanu...
These tumors express high levels of INHBB (encoding ActivinB) and display high expression of PMEPA1, a well-known target gene of this signaling pathway. Functionally, the pathway sustains cell proliferation by inducing the expression of PMEPA1. Importantly, treatment with Galunisertib, an ...
Complex mechanisms, which are often context dependent, have evolved to check and modulate the potent activity of TGFb ligands in controlling cell behaviour and tissue homoeostasis8,9. Although the regulation of the TGFb pathway occurs at multiple layers of the signalling cascade, R-SMADs, as ...
别名Apoptosis Related Protein TGFb Signalling; Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; bradeion; Bradeion beta; Brain protein H5; CE5B3; CE5B3 beta; cell division control-related protein 2; cerebral protein 7; H5 antibody hCDCREL-2; hucep-7; peanut-like 2; Peanu...
MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC The LIN28B→let-7 pathway contributes to regulation of the epithelial-mesenchymal transition (EMT) and stem cell self-renewal. The oncogenic MUC1-C transme... Maroof,Alam,Rehan,... - 《Molecular Cancer Resea...
Increase of regu latory T cells in theperiph eralb lood of cancer pat ien ts [ J] . C lin C ancer Res, 2003;9( 2) : 606-612. [14]Jarv is L B, M atyszakM K, Duggleby R C et al. Au toreact ive hum an peripheral b lood CD8+ T cellsw ith a regu latory phenotype and...
Objectives The transforming growth factor-β (TGFB) pathway has substantial impact on cellular functions, cell proliferation, and apoptosis. We used bioinformatics, gene expression, and cell biological assays to evaluate the functionality of frequent inherited germline polymorphisms in the TGFB receptor 1...
cell migration, axon growth and gastrulation movements.9 Integration of Smad activity and canonical Wnt signaling has received considerable attention.10–12 Instead, here we explored the crosstalk of TGFb with Dishevelled (Dvl) and Par1b, in the context of noncanonical Wnt signaling and and Smad4...
Transforming growth factor (TGF)-β signaling disorder has emerged as a common molecular signature for aortic aneurysm development. The timing of postnatal maturation plays a key role in dictating the biological outcome of TGF-β signaling disorders in t
Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion. Expansion of the mouse cumulus-oocyte complex (COC) is dependent on oocyte-secreted paracrine factors. Transforming growth factor beta (TGFB) superfamily m... RA Dragovic,LJ Ritter,SJ ...