Hesketh, RobinSCOLLEN S, LUCCARINI C, BAYNES C et al. (13 authors). TGF-β signalling pathway and breast cancer susceptibility. Cancer Epidemiol. Biomarkers Prev., 2011, 20:1112-19.Scollen, S. et al. TGF-β signalling pathway and breast cancer susceptibility. Cancer Epidemiol Biomarkers ...
Signalling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, whichcatalysesthephosphorylationof the Type I receptor. Each class of ligand binds to a specific type II receptor[2].In mammals ...
参考文献 1. Akhurst RJ, Hata A. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov. 2012;11(10):790-811.2. Lewis KA, et al. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 2000;404(6776):411-414.3. Heldin CH, Moustak...
New insights into TGF-beta-Smad signalling. TGF-beta signalling components and the activity of other signal transduction pathways, which can either synergize with or antagonize the TGF-beta pathway. Re... DP Ten,CS Hill - 《Trends in Biochemical Sciences》 被引量: 2378发表: 2004年 Activin/TGF...
Wnt signalling modulates transcribed-ultraconserved regions in hepato- biliary cancers. Gut 2016; 66: 312278. 12 Ferdin J, Nishida N, Wu X, Nicoloso MS, Shah MY, Devlin C et al. HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts. Cell Death Differ 2013; 20: 1675–1687...
The transforminggrowth factor-beta (TGF-β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post-natal beta cell growth has only been recently reported. Materials and methods Here, we studied the role of TGF-β receptor ...
(Fig.5a). To characterize specifically the importance of TGFβ signalling in myogenic cells we crossed theTgfbr2flx/flxstrain to theMyoD-Cre mouse line32and analysedMyoD-Cre:Tgfbr2flx/flxembryos and postnatal mice. Embryonic diaphragm development inMyoD-Cre:Tgfbr2flx/flxwas normal, fully ...
TGF-β signalling pathways, illustrated inFig. 16.3, are activated upon dual receptor binding, whereby TGF-β and its receptors cause the phosphorylation of many intracellular pathways, particularly the Smad pathway, c-Jun-N-terminal kinase (JNK) pathway, phosphatidylinositol-3-OH kinase (PI3K) pat...
Integrin signalling regulates YAP and TAZ to control skin homeostasis The skin is a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that... A Elbediwy,Zoé I. Vincent-Mistiaen,Bradley Spencer-Dene,... ...
The transforming growth factor-beta (TGF-beta) signalling pathway is a key mediator of fibroblastactivation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Herewe demonstrate a novel link between transforming growth factor-beta and the canonical Wntpathway. TGF-beta stim...