The RAS / RAF / MEK / ERK Pathway Part 3 - RAS/RAF/MEK/ERK信号通路3 504 -- 17:27 App 【信号转导通路】Signal Transduction Pathways (G-Protein, Receptor Tyrosine Kinase, cGMP) 214 -- 11:04 App The RAS / RAF / MEK / ERK Pathway Part 4 - RAS/RAF/MEK/ERK信号通路4 439 -- 38...
17 p. 细胞信号通路与癌症发生 14 p. 细胞信号通路大全66121103 14 p. 细胞信号通路大全03032 15 p. 细胞信号通路与癌症.pdf 13 p. Transforming Growth Factor (TGF) Beta Pathway 1 p. 【细胞信号通路】Ras_Pathway 发表评论 验证码: 换一张 匿名评论 提交 关于...
TGF_Beta_Pathway之经典信号通路.ppt,P TGFb Pathway p300 Cytokine Receptor Cytokine LTBP/ LAP Latent TGFb TGFbR II TGFbR I Latent TGFb P P XIAP HPK1 TAK1 TAB1 TAB1 TAK1 SARA PP2A Post Transcriptional G1 Arrest SMADs SMAD6 SMAD3 SMAD3 SMAD2 SMAD2 SMAD2 SMAD
The TGF beta pathway is involved in the regulations of cellular proliferation, differentiation, embryogenesis and apoptosis. View our interactive pathway.
TGF-β信号参与多种细胞(包括胶质瘤细胞)的增殖、分化、存活/或凋亡的调节。TGF-β通过特异性受体激活多个细胞内通路发挥作用,使受体调控Smad2/3蛋白发生磷酸化,同时也是Smad4的调节因子。在细胞核内磷酸化的RSMAD与coSMAD(如SMAD4)形成复合体,然后与DNA结合并调控多种基因的转录。此外,TGF-β活化激酶-1(TAK1)...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44.10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. ...
TGF_Beta_Pathway TGFbPathway LTBP/LatentLAPTGFbLatentTTGFbGF b RI PP GrowthFactorsSARAPP2AGrowthPFactorGRB2ReceptorSHCSMADsSOS XIAP HPK1 TAK1 SMAD6 P Ras Ras SMAD7 P GTP P GDP PI3K PP SMAD2SMAD3 RhoA MEKsTumorigenesisAkt/PKB MKK3 MKK4EpithelialMesenchymalTransdifferentiation P P SMAD3SMAD4 P ...
The TGFBeta pathway has recently emerged as a putative therapeutic target against cancer. However, TGFBeta has a complex and dual role in cancer. In normal epithelial cells and early tumours, TGFBeta acts as a tumour suppressor. In contrast, during tumour progression TGFBeta becomes an oncogenic...
TGF beta signaling pathway批注本地保存成功开通会员云端永久保存去开通 TGF beta signaling pathway TheTransforming growth factor beta (TGFβ) signaling pathwayis involved in many cellular processes in both the adult organism and the developingembryoincludingcell growth,cell differentiation,apoptosis, cellular ...
TGFbetasignalingpathwayTheTransforminggrowthfactorbeta(TGFβ)signalingpathwayisinvolvedinmanycellularprocessesinboththeadultorganismandthedevelopingembryo..