Abstract 16407: Transforming Growth Factor-β Type 1 Receptor Gene (TGFBR1) Mutations Impairs Neural Crest Stem Cell (NCSC)-Derived Smooth Muscle Cells Differentiation From Human Pluripotent Stem Cells (hPSCs)doi:10.1161/circ.138.suppl_1.16407
other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. ...
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated wit...
TGFBR1 (TGF-beta receptor type-1) encodes a serine/threonine kinase receptor for transforming growth factor-beta. TGFB1, TGFB2 and TGFB3 signals are transduced from the cell surface to the cytoplasm and regulate lots of physiological and pathological processes including cell cycle arrest in epithel...
Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. 基因名: TGFBR3 别名: BGCAN,betaglycan 基因ID: 7049 Chromosome:(GRCh37) 1 Start: 92145902 End: 92371892 Strand: -1 ...
TGFBR3 (Transforming Growth Factor Beta Receptor 3) is a protein coding gene located on human chromosome 1p22.1. TGFBR3 is also known as BGCAN and betaglycan. The human TGFBR3 gene encodes a 93499 Da protein containing 851 amino acids. The TGFBR3 protein is ubiquitously expressed in fat, ...
Full Name transforming growth factor, beta receptor III Observed Molecular Weight 130 kDa GenBank Accession Number BC136295 Gene Symbol TGFBR3 Gene ID (NCBI) 7049 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification Storage Buffer PBS with 0.02% sodium azide and 50% gl...
别名 TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN 观测分子量 130 kDa GenBank蛋白编号 BC136295 基因名称 TGFBR3 Gene ID (NCBI) 7049 RRID AB_3086094 偶联类型 Unconjugated 形式 Liquid 纯化方式 Antigen affinity purification UNIPROT...
TGFBR1(transforming growth factor, beta receptor 1) 基因基本信息 基因简称(symbol) TGFBR1 [HGNC] [GeneCards] [NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) ALK-5|ACVRLK4 基因家族代码(gene_family_id) 345 [HGNC] [GenScript] omim代码 190181 entrez码 7046 [...
Genetic analyses have shown that the Tgfβ receptor 1 (Tgfbr1) (also known asAlk5) plays a key role in the activation of the trunk to tail transition, also initiating the regulatory sequence controlling formation of the hindlimb and external genitalia2,37,38. Indeed,Tgfbr1null mutant embryos...