To improve the therapeutic index of CA9 CAR T cells, we developed an "AND" logic gated ICT cell that requires the presence of two antigens to trigger tumor cell killing, thereby enhancing tumor specificity. Induction of the CA9 CAR is gated on the expression of PSMA found on the tumor ...
M Pizzato, M Li, J Vignat, M Laversanne, D Singh, C La Vecchia, S Vaccarella The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020 Lancet. Diabetes and Endocrinology, 10 (2022), pp. 264-272 https://doi.org/10.1016/S2213...
The sections were subsequently incubated in 3% hydrogen peroxide/methanol and then in 0.25% pepsin (Dako, Carpinteria, CA, USA) to retrieve the antigens. Next, the samples were blocked in a blocking solution (Dako), incubated at 4 °C overnight with primary antibodies, washed with TBST ...
Currently there are few clinical therapies directly targeting PF. Immunosuppressive and immunomodulatory therapies such as prednisone, azathioprine and N-acetyl-L-cysteine have been proven ineffective9. Monoclonal antibodies targeting TNFα (etanercept)10and CC-chemokine ligand 2 (CCL2, carlumab)11also ...
(hereafter referred to as SUM159) derived from a patient with ana- plastic carcinoma, an inflammatory invasive ductal carci- noma SUM149PT (SUM149), a pleural effusion derived SUM229PE (SUM229) and tumor cells derived from metastatic nodule of a patient with infiltrating ductal car- cinoma ...
参考资料:1. Tang, N. et al. TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors. JCI Insight 5, e133977 (2020). 因为这周六要做文献分享,Krishnamurty, A. T.et al.LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity...
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