BCL11B表达降低预示着CLL患者的TTFT和OS更短 为了研究BCL11B单独或联合TCF1对CLL患者预后的影响,该研究分别在GSE39671和GSE22762数据集中进一步分析了BCL11B对CLL患者TTFT和OS的影响。与高表达组相比,BCL11B的低表达与较短的TTFT和较差的OS显著相关(5年TTF...
Here, we demonstrate using an immune-competent mouse model of B cell acute lymphoblastic leukemia (B-ALL) that Regnase-1 deficiency promotes TCF-1 expression to enhance CAR-T cell expansion and memory-like cell formation. This leads to improved CAR-T-mediated tumor clearance, sustained remissions...
FOXO1 is a master regulator of memory programming in CAR T cells Alexander E. Doan Katherine P. Mueller Evan W. Weber Nature(2024) Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
TCF1 and its homologue LEF1 are historically known as effector transcription factors downstream of the WNT signalling pathway and are essential for early T cell development. Recent advances bring TCF1 into the spotlight for its versatile, context-dependent functions in regulating mature T cell respons...
cultured in vitro, promotes the conversion of CD8+ T cells to long-lived memory T cells (Tm), promotes TCF1 expression in CD8+ T cells, reduces their depletion and apoptosis, and thus enhances the anti-tumor ability of CD8+ chimeric antigen receptor T-cell transfusion (CAR-T) [25,26,...
Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, we identified two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12. One is a complex t(15;21)(q24;q22), with both breakpoints mapped at the nucleotide...
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt signaling, although there is strong eviden...
TCF-1: a maverick in T cell development and function Article 29 April 2022 FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells Article 27 November 2023 Data availability The Hi-C, DNase-seq, RNA-seq and CTCF CUT&RUN data in IL-7 +...