BCL11B表达降低预示着CLL患者的TTFT和OS更短 为了研究BCL11B单独或联合TCF1对CLL患者预后的影响,该研究分别在GSE39671和GSE22762数据集中进一步分析了BCL11B对CLL患者TTFT和OS的影响。与高表达组相比,BCL11B的低表达与较短的TTFT和较差的OS显著相关(5年TTF...
本发明涉及基因工程领域,具体涉及转录因子TCF1在抵抗CAR-T细胞耗竭和终末分化中的应用。 背景技术 1.1嵌合抗原受体T细胞疗法的成就和局限 嵌合抗原受体T细胞(chimeric antigen receptor-modified T cell,CAR-T)疗法是利用基因工程技术对T细胞进行基因改造后,使其表达能够特异性识别肿瘤抗原的嵌合抗原受体并对肿瘤细胞发动免...
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt signaling, although there is strong eviden...
cultured in vitro, promotes the conversion of CD8+ T cells to long-lived memory T cells (Tm), promotes TCF1 expression in CD8+ T cells, reduces their depletion and apoptosis, and thus enhances the anti-tumor ability of CD8+ chimeric antigen receptor T-cell transfusion (CAR-T) [25,26,...
(12)BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustionScience translational medicineNovember 9, 2022Jung IY, Narayan V, McDonald S, Rech AJ, Bartoszek R, Hong G, Davis MM, Xu J, Boesteanu AC, Barber-Rotenberg JS,et al.Granzyme...