Further, in HCC cells with loss of response to TGF-\\#946;, NSC 74859, a STAT3-specific inhibitor markedly suppresses growth. In addition, liver cancer cells with impaired TGF-beta signaling have two to four fold decrease in STAT3 phosphorylation at Ser727 (pSTAT3). Here we report ...
In order to demonstrate that these changes were due toTgf-βsignaling, we inhibited TGFβR-1, which inhibits TGFβ-1 dependent SAMD3 phosphorylation and subsequent downstream signaling. This resulted in a decrease in the average gene expression ofCtgf, Tgfβ-1, Tgfβ-2, Col-IVa, andMmp-9...
IL-6 and oncostatin M (OSM) belong to the same family of cytokines; their cell-surface receptors share the signal-transducing subunit gp130 and induce intracellular signaling through STAT3; both are well known for their profibrotic regulation in cell culture and in vivo; and blockade of these ...
Effect of TLR4 on the growth of siha human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-κb-cyclin D1-STAT3 signaling pathways The present study aimed to investigate the effect of Toll‑like receptor 4 (TLR4) on SiHa human cervical cancer cells and its potential molecular biolog...
机译:乙型肝炎病毒X蛋白通过激活JAK2 / STAT3信号通路调节人肾近端肾小管上皮细胞的凋亡 PING HE ,DAN ZHANG ,HONG LI -1 7.Shenning II Decoction Inhibits Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Regulation of Wnt/iβ/i-Catenin Signaling and spring 机译:Shenning II...
Alantolactone 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 Apoptosis ¥ 194 现货 规格 数量 客户已引用 选择批次: 浓度:3.03 mg/mL 纯度:SDS-PAGE:95% SEC-HPLC:95% 联系我们获取更多批次信息 资源下载 DataSheetSDSCOA产品操作手册 ...
INHBAINHBBInhibinInhibin AInhibin B Activin Receptors - Products by Molelcule Activin RIA/ALK-2Activin RIB/ALK-4Activin RIIAActivin RIIA/BActivin RIIB Activin Family Modulators - Products by Molecule FollistatinFollistatin-like 1/FSTL1Follistatin-like 4/FSTL4Follistatin-like 5/FSTL5Follistatin-relate...
Alantolactone 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 Apoptosis ¥ 194 现货 规格 数量 客户已引用 "BMS986260"的相关化合物库 抗纤维化化合物库 Anti-Fibrosis Compound Library L98101800 化合物 获取报价 抗结直肠癌化合物库 ...
Alantolactone 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 Apoptosis ¥ 194 现货 规格 数量 客户已引用 "Vactosertib"的相关化合物库 膜蛋白靶向化合物库 Membrane Protein-targeted Compound Library L15204175 化合物 获取报价
Alantolactone 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 Apoptosis ¥ 194 现货 规格 数量 客户已引用 "Chromenone 1"的相关化合物库 抗纤维化化合物库 Anti-Fibrosis Compound Library L98101800 化合物 获取报价 神经元分化化合物库 ...