TGF-β signaling pathway-related genes in predicting the prognosis of colon cancer and guiding immunotherapyColon cancerPrognosisRisk signatureImmune microenvironmentImmunotherapyTwo transforming growth factor-β (TGF-β) subtypes were identified using consensus clustering.The TGF-β high subtype was associated...
RANK Signaling in Osteoclasts Stem Cell Biology Pathways TGF-β 信号转导通路 THC Differentiation Pathway TNF 信号传导通路 TNF Superfamily Pathway Transcription Factors Pathways Transendothelial Migration of Leukocytes Tumoricidal Effects of Hepatic NK Cells T...
TGF-beta Signaling Regulates the Expression of Multiple Target Genes with Tumor-Suppressing & Tumor-Promoting Effects TGF-beta-Induced Epithelial-to-Mesenchymal Transition Promotes Breast Cancer ProgressionPopular Products ELISA试剂盒 一抗体 多因子定量分析(Luminex液相芯片) 小分子 生物活性蛋白 市场活动 Compan...
[60] Hinshelwood RA, Huschtscha LI, Melki J, et al. Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res 2007;67:11517-27. [61] Wang X, Sun DF, Lu R, et al. RAF may induce cell proliferation through ...
The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. It functions through canonical SMAD-mediated processes and noncanonical pathways involving MAPK cascades, PI3K/AKT, Rho-like GTPases,...
nucleus, but signaling causes the Smads to accumulate predominantly in the nucleus where they bind DNA and other transcriptional machinery to regulate the expression of target genes. Abnormalities of the TGF-beta receptors and SMADs have been detected in various tumors, including colorectal cancers and...
In contrast to the previously identified genes belonging to the machinery necessary for fusion, the TGFβ pathway acts as a molecular brake in this process. We had previously observed that during early embryonic development, the rate of muscle fusion in trunk was about 2.5 times slower than in ...
research concerning the role of TGF-β in regulating the TCA cycle remains to be explored. Inhibition of the TGF-β pathway through knockdown of TGF-βRI in hepatocellular carcinoma SNU449 cells correlates with reduced expression of PPP-related genes, including G6PD, hexose-6-phosphate dehydrogenase...
The Transforming Growth Factor Beta (TGF-) signaling pathway is one of the most commonly disrupted pathways in colorectal cancer. Its deregulation appears to mediate cancer formation through a variety of mechanisms. TGF- is the canonical member of a family of secreted proteins that include the TGF...
J. Large- and small-molecule inhibitors of transforming growth factor-beta signaling. Curr. Opin. Investig. Drugs 7, 513–521 (2006). CAS PubMed Google Scholar Washio, H. et al. Transcriptional inhibition of hypertrophic scars by a gene silencer, pyrrole-imidazole polyamide, targeting the ...