9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44.10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. ...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8...
具有口服生物活性的 TGF-beta 信号通路的激活剂,具有神经保护作用。 TGF-beta/Smad 化合物库 100+ 种 TGF-β/SMAD 信号相关小分子化合物,是 TGF-β/SMAD 信号通路相关药物筛选和疾病研究的有用工具。 TGF-β 受体抑制剂/激动剂 TGF-β 受体是单通道丝氨酸/苏氨酸激酶受体,TGF-β 超家族成员通过受体复合体发...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19...
2024年10月19日,中国科学院遗传与发育生物学研究所田烨研究组在《Nature Communications》杂志在线发表研究文章“ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade”。该研究揭示了TGF-β信号通路调控神经-肠道的...
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982.7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8(9):960. Published 2019 Aug...
转化生长因子 (Transforming growth factor beta,TGF-β) 是一类多功能的细胞因子,可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子,与相应的受体、细胞内信号转导分子组成的通路,能影响疾病发生和发展,调节基因的转录,控制着细胞周期,影响细胞的增殖、分化、黏附、转移和凋亡。值得注意的是,TGF...
转化生长因子-β(TGF-β)是一类具有广泛生物学活性的细胞因子,当它与相应的受体结合时,能够激活Smad与非Smad信号通路,从而触发一系列复杂的生物学效应,包括促进肿瘤细胞的免疫逃逸、同时展现出抑癌和促癌的双重作用。鉴于其在细胞功能和疾病发展中的重要作用,科学家们对以该通路蛋白作为治疗靶点的研究兴趣日益浓厚。其...
9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. 10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139. ...