9. Varelas X, Wrana JL, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44.10. Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009; 19(1):128-139.11. Massagué J. ...
基因表达谱芯片结果显示, 经GMA诱导16HBE细胞恶性转化后期差异表达基因通路涉及TGF.8信号系统(TGF-betasignalingpathway-Homosapiens(human)),其已被揭示与多种人类肿瘤相关,且其改变也与肿 瘤的发展和预后密切相关。1。 TGF-IB(transforminggrowthfactorbeta,转化生长因子6)是一种多功能的多肽类细胞 因子。TGF能够...
TGF-beta信号通路研究背景 TGF-β信号参与多种细胞(包括胶质瘤细胞)的增殖、分化、存活/或凋亡的调节。TGF-β通过特异性受体激活多个细胞内通路发挥作用,使受体调控Smad2/3蛋白发生磷酸化,同时也是Smad4的调节因子。在细胞核内磷酸化的RSMAD与coSMAD(如SMAD4)形成复合体,然后与DNA结合并调控多种基因的转录。此外,T...
TGF beta signaling pathway批注本地保存成功开通会员云端永久保存去开通 TGF beta signaling pathway TheTransforming growth factor beta (TGFβ) signaling pathwayis involved in many cellular processes in both the adult organism and the developingembryoincludingcell growth,cell differentiation,apoptosis, cellular ...
近日,美国《生物化学杂志》(Journal of Biological Chemistry)在线发表了中科院上海生命科学研究院营养科学研究所陈雁研究组的最新研究成果Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-beta signaling pathway。该研究发现一个接头蛋白Tollip能与Smad7协同作用,影响...
Signaling pathwayLiver diseasesPharmacological targetTargeted drugsTransforming growth factor beta (TGF-beta) belongs to a class of pleiotropic cytokines that are involved in the processes of embryonic development, wound healing, cell proliferation, and differentiation. Moreover, TGF-beta is also regarded ...
[5]. Nan Wu, et al. LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ. 2021 Jan;28(1):219-232. [6]. Hai Zhang, et al. Effects of transforming growth factor-beta 1 (TGF-beta1) on in...
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. 化学信息 分子量 329.48 分子式 C20H31N3O CAS No. 1629138-41-5 Smiles O=C(NC1CCCCC1)N(CC1CCNCC1)Cc1ccccc1 密度 no data available 储存&溶解度 存储 Powder: -20°C ...
Key words:TGF beta1 / Smad;signaling pathway;renal interstitial fibrosis;traditional Chinese medicine single drug;compound tradi tional Chinese medicine 肾间质纤维化(renal interstitial fibrosis,RIF)是各种慢性 进行性肾脏疾病渐进发展到终末期肾功能衰竭的共同形态 学特点和必然结局 [1] 。近年来中医药防治...