第一篇 TGF-β Signaling doi:10.3390/biom10030487 Activation of latent TGF-β. The TGF-β/SMAD signaling pathway. Internalization and intracellular sorting of TGF-β receptors. Schematic representation of structure of the SMAD proteins. The TGF-β non-SMAD signaling pathways. 第二篇 TGF-β rec...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982.7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; 8...
TGF beta's, Activins, Nodals and some GDFs are mediated by SMAD2 and SMAD3, while BMPs, AMH and a few GDFs are mediated bySMAD1,SMAD5andSMAD9. The binding of the R-SMAD to the type I receptor is mediated by a zinc double finger FYVE domain containing protein. Two such proteins ...
TGF beta pathway activation and the SMAD signaling pathway Before binding to its receptors, TGF beta is activated from a large latent complex comprised of LTBP and LAP (Latency Associated Peptide). Ligand binding to the Type II receptor (TGF betaRI...
1.Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy. Int Immunopharmacol. 2020 Oct 21;89(Pt B):107101. 2.Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity. Cancers (Basel). 2020 Oct 23;12(11):E30...
Attenuation of the TGF--Smad signal- ing pathway in pancreatic tumor cells confers resistance to TGF--induced growth arrest. Oncogene 22:3698-3711.Nicolas FJ, Hill CS (2003) Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-...
TGF-beta/Smad PKC TGF-β Receptor Overview of TGF-beta/Smad The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. These proteins were identified mainly through their roles in development; they regulate the establishment of the body plan and...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; ...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma. Cells. 2019; ...
6. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol. 2007;8(12):970-982. 7. Papoutsoglou P, Coulouarn C, et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in ...