Wang CL, Wan YL, Liu YC, Huang ZQ (2006) TGF-beta1/SMAD signaling pathway mediates p53- dependent apoptosis in hepatoma cell lines. Chin Med Sci J 21: 33-35. PMID: 16615282Chun-lei Wang 1*, Yuan-lian Wan 1, Yu-cun Liu 1, and Zhi-qiang Huang 2 1Department of General Surgery, ...
Key words:TGF beta1 / Smad;signaling pathway;renal interstitial fibrosis;traditional Chinese medicine single drug;compound tradi tional Chinese medicine 肾间质纤维化(renal interstitial fibrosis,RIF)是各种慢性 进行性肾脏疾病渐进发展到终末期肾功能衰竭的共同形态 学特点和必然结局 [1] 。近年来中医药防治...
Previously, we reported that Smad7, a negative regulator of Smad signaling, might be a molecular linking between the Nrf2 pathway and Tgf-beta1 signaling in human renal tubular epithelial HK2 cell. In this study, we confirmed that elevated protein level of Smad7 attenuates Tgf-beta1 signaling ...
TGF-β/Smad3 signaling promotes fibrosis, but the development of therapeutic interventions involving this pathway will require the identification and ultimate targeting of downstream fibrosis-specific genes. In this study, using a microR... Q Wei,ACK Chung,RH Xiao,... - 《Journal of the American...
SSc fibroblasts are potentially derived from various cellular origins, which could contribute to phenotype heterogeneity as a result of diverse signaling pathway activation. In this work, the role of TGF-beta/Smad1 signaling in SSc fibrosis was examined in three models of SSc; hTERT clonal cell ...
Forsythiaside B down-regulated the expression of Smad4 and the phosphorylation level of Smad3, which indicates that forsythiaside B could suppress myocardial fibrosis by inhibiting the TGF-beta 1/Smad signaling pathway. These results demonstrated that forsythiaside B could prevent myocardial fibrosis ...
The TGF-beta 1/Smad signaling pathway is involved in EMT and contributes to migration and invasion in RA-FLSs. Interestingly, vimentin decreased in RA-FLSs, but there is no correlation between vimentin and TGF-beta 1/Smad signaling pathway. Thus, further research on vimentin should be conducted...
摘要: expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression. These data show that TGF-β-induced NFκB activation is through TAK1/MEK-mediated AKT activation, which is essential for TGF-β to support of osteoclast survival.关键词:...
Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type II... Both transforming growth factor beta (TGF-β) and p53 have been shown to control normal cell growth. Acquired mutations either in the ...
Previous studies have shown that the transforming growth factor-beta 1 (TGF-beta 1)/Smad signaling pathway plays a key role in the development of myocardial fibrosis in DCM. Silymarin (SMN) is used clinically to treat liver disorders and acts by influencing TGF-beta 1. However, the possible ...