Cardiac fibrosisCancerTransforming growth factor-beta 1 (TGF-beta 1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother against decapentaplegic (Smad) signaling. Different TGF-beta signalings play different roles in ...
Although transient TGF-[beta]1 activity participates in repair and regeneration of tissues, persistent TGF-[beta]1 function affects excessive fibrosis and ultimately scarring of both skin and internal organs. Scarring of internal organ (e.g., liver and lung) ...
Conversely, members of both miR-29 and miR-200 families are negatively regulated by TGF-尾/Smad3 and play a protective role in renal fibrosis by ... L Hui,C Arthur,X Yu - 《International Journal of Nephrology & Renovascular Disease》 被引量: 122发表: 2013年 Etiopathology of chronic tubul...
Key words:TGF beta1 / Smad;signaling pathway;renal interstitial fibrosis;traditional Chinese medicine single drug;compound tradi tional Chinese medicine 肾间质纤维化(renal interstitial fibrosis,RIF)是各种慢性 进行性肾脏疾病渐进发展到终末期肾功能衰竭的共同形态 学特点和必然结局 [1] 。近年来中医药防治...
Transforming growth factor-beta (TGF-beta) signaling and TGF-beta-promoted epithelial-to-mesenchymal transition (EMT) have been postulated to be the common pathway causing pulmonary fibrosis. However, the up-or downstreaming markers of T... F Sun,K Hu - 《Disease Markers》 被引量: 0发表: ...
and extracellular matrix remodeling. Generally, signaling is initiated with the phosphorylation of the cytoplasmic Smad signaling molecules, which results in their translocation to the nucleus where they modulate transcription. TGF-βs are often overexpressed in many disease states such as fibrosis, inflam...
Opposite effects of TGF-beta1 and IFN-gamma on transdifferentiation of myofibroblast in human gingival cell cultures. Background/Aim: Previously, we have shown that myofibroblasts, the main cell type associated with interstitial fibrosis, may be implicated with the gingiva... LM Sobral,PF Montan,H...
Sauchinone Protects Renal Mesangial Cell Dysfunction against Angiotensin II by Improving Renal Fibrosis and Inflammation. Abnormal and excessive growth of mesangial cells is important in the pathophysiologic processes of diabetes-associated interstitial fibrosis and glomerulos... JJ Yoon,HK Lee,HY Kim,....
A previous study suggested that TGF-b1 is closely associated with the extracellular matrix of the myocardium and is involved in both cell interstitial fibrosis and extracellular matrix deposition.22 The TGF-b1 levels were moderately decreased in the uc.4 overexpression group (Figure 6e). ECM-...
Sustained expression of TGF-beta 1 underlies development of progressive kidney fibrosis. We found that TGF-beta 1 expression and increased matrix production is transient and self-limited in nephritic glomeruli from rats with acute, reversible glomerulonephritis induced by a single injection of an ...