转化生长因子-β(TGF-β)超家族在衰老、免疫调节、动脉粥样硬化和组织纤维化的生理和病理过程中发挥着至关重要的作用。近期,《Aging and Disease》期刊发表题为“TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis“...
Recent studies suggest that pirfenidone (a medication that down regulates the expression of TGF-B1 and fibroblasts in scar tissue) slows down the inflammatory process resulting in reduced fibrosis and inflammation. This study aims to explore the effect of TGF-B1 receptor inhibition on skin scars, ...
Cardiovascular Research Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway OxfordJournals: source Immunopharmacology and Inflammation Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmiani...
TGF beta 1/TGFB1 Protein plays a driving role in development, fibrosis and cancer. 蛋白编号:P01137 (A279-S390) 基因ID:7040 产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 转化生长因子β | 转化生长因子-β1 | 细胞因子和生长因子 | 神经营养因子 | 转化生长因子-β | 转化生长因子...
Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. In Drug Dev Res on 2022 Jun by Feng Wang, Jun Zhang,et al..PMID:35277868,, (2022), ...
Additionally, TGF-β1 has been studied in the context of fibrotic diseases, such as pulmonary fibrosis and liver fibrosis, where it is implicated in the fibrotic cascade. Furthermore, TGF-β1 has been explored as a potential target for antitumor therapies due to its involvement in tumor ...
For example, activation of Nrf2 attenuates TGFb1-induced liver and lung fibrosis (Nakam- ura et al., 2011; Oh et al., 2012b). In airway smooth muscle cells, the profile of increased TGFb1 and diminished Nrf2 is observed in patients with reactive airways (Michaeloudes e...
matrix synthesis and modulating the immune response. TGF-β1 also has immunomodulatory functions, influencing the differentiation and function of immune cells. However, dysregulation of TGF-β1 signaling is associated with various pathologies, including cancer progression, fibrosis, and autoimmune disorders...
Purpose:The transforming growth factor beta1 (TGFB1) pathway has been linked tofibrosis in several tissues including skin, liver, kidney and the cornea. In this study, a RNA interference-based approach using siRNAs targeting three critical scarring genes, TGFB1, TGFB receptor 2(TGFBR2) and ...
Recent studies suggest that pirfenidone (a medication that down regulates the expression of TGF-B1 and fibroblasts in scar tissue) slows down the inflammatory process resulting in reduced fibrosis and inflammation. This study aims to explore the effect of TGF-B1 receptor inhibition on skin scars, ...