结论Tfli亚型紊乱与HSP的发生密切关联,其中外周血 P D-1 *Tfti可能通过介导ICOS、OX40信号通路而调控HSP的发生与发展。 [关键词]过敏性紫癜;滤泡辅助性T细胞;协调刺激信号分子;0X40;程序性死亡受体1 [中图分类号]R373.3+1 [文献标识码]A Immunological mechanism of PD-1+TFH mediated ICOS and 0X40 ...
We found that PD-1-/-na茂ve and immunized mice had more TFR cells in the spleen than WT and WT immunized mice. Additionally, CXCR5+DC, which prime TFH cells, were activated at similar levels in ITV-immunized WT and PD-1-/-mice. However, the serum levels of IL-10, IFN-纬 and ...
展开更多 Objective To investigate the expression and clinical significance of T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain(TIGIT)and programmed cell death protein 1(PD-1)on T follicular helper cells(Tfh)in peripheral blood of patients with chro...MORE 作者 张瑞 ...
Programmed death receptor-1 (PD-1) inhibitors improve survival outcomes by offering a durable response in patients with non-small cell lung cancer (NSCLC)4,5,6,7. Accordingly, these inhibitors are used as first- and second-line therapies for NSCLC4,5,6,7. With the increase in the number ...
The frequency of Tfh (CD4 +CXCR5+PD-1+) cells, total B (CD19+) cells nave B (CD19 +CD27-) cells, memory B(CD19 +CD27+) cells and plasmablasts (CD19 +CD38++) were examined by flow cytometry. The serum levels of IL-21, IgG, IgM, IgE and IgA were tested by enzyme linked ...
and support B cells. In addition, these CXCR3+PD-1loTfh-like cells contained higher proportions of stem cell–like memory T cells, and upon antigenic stimulation differentiated into PD-1hiTfh-like cells in a Notch-dependent manner. Together, these data suggest that CXC...
Percentage of TFH and expression of CXCR5 and PD-1 during fingolimod treatment in MS patients.Nele ClaesTessa DhaezeJudith FraussenBieke BrouxBart Van WijmeerschPiet StinissenRaymond HuppertsNiels HellingsVeerle Somers
Inducible co﹕timulator﹑ositive (ICOS) and programmed death 1﹑ositive (PD are important markers for follicular helper T cells (Tfh), however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. ...
Circulating CXCR5+CXCR3+ PD-1lo Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth. JCI In- sight e89574, 2.Martin-Gayo E, ... Enrique,Martin-Gayo,Jacqueline,... - 《Jci Insight》 被引量: 14发表: 2017年 Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[su...
In addition, the absence of PDL1 resulted in increased fetal resorption by favoring Tfr cells accumulation and upregulating PD-1 expression on these cells. However, PDL1 blockade affected neither the ratio of Tfh/Tfr cells nor the maturation and differentiation of B cells. Overall, our results ...