细胞因子（Cytokines）是一类可溶性分子信使，可响应抗原呈递细胞刺激，在体内激活和传递抗病免疫级联反应。...
12月5日,斯丹赛生物技术有限公司(Innovative Cellular Therapeutics, ICT)宣布,针对CD19靶点并表达显性阴性(dominant negative)PD-1分子来阻断肿瘤免疫抑制通路的新一代“装甲”CAR-T产品--ICTCAR014被美国FDA批准临床。斯丹赛将于2020年开始在美国招募肿瘤细胞表面表达PD-L1的复发难治型非霍奇金淋巴瘤(r/r NHL)患者。
目的:探讨外周血程序性细胞死亡分子1(PD-1)及血清中Th1/Th2型细胞因子变化在原因不明复发性流产(URSA)发病中的作用.方法采用流式细胞术测定140例URSA患者接受淋巴细胞免疫治疗前后外周血PD-1水平;采用ELISA法测定患者治疗前后血清Th1(IL-2,IFN-γ)/Th2(IL-4,IL-10)型细胞因子水平,同时以10...
不明原因复发性流产患者外周血Th1/Th2和单核细胞上Tim-3、PD-1表达及临床意义 海南西部中心医院(儋州,571700) Expressions and clinical significances of Th1/Th2 cytokine in peripheral blood, and Tim-3 and PD-1 in peripheral blood mononuclear cells of women with unexplained recurrent miscarriage Hainan ...
摘要 目的探讨晚期非小细胞肺癌(NSCLC)合并慢性阻塞性肺疾病(COPD)患者外周血辅助性T细胞1/辅助性T细胞2(Th1/Th2)、辅助性T细胞17/调节性T细胞(Th17/Treg)与程序性死亡受体1(PD-1)抑制剂疗...展开更多 ObjectiveTo investigate the relationship between peripheral blood helper T cell 1/helper T cell 2(Th1/...
测定外周血单核细胞上的Tim-3、PD-1表达水平,Th1/Th2细胞因子白介素-2(IL-2)、IL-12、γ-干扰素(IFN-γ)、IL-4、IL-6、IL-10.结果:URSA组和TA组的单核细胞上Tim-3、PD-1表达水平均低于健康早孕组且URSA组低于TA组,外周血IL-2、IL-12、IFN-γ水平均高于健康早孕组且URSA组高于TA组,外...
PD-1proallergic TH2T-cell exhaustionBackground Studies show that proallergic T(H)2 cells decrease after successful allergen-specific immunotherapy (AIT). It is likely that iatrogenic administration of allergens drives these cells to exhaustion due to chronic T-cell receptor stimulation. This study ...
PD-1; PD-L2; Th2 cells; Dendritic cells; Regulatory T cells Abstract Programmed death-1 ligand 2 (PD-L2) is a ligand for programmed death-1 (PD-1), a receptor that plays an inhibitory role in T cell activation. Since previous studies have shown up-regulation of PD-L2 expressio...
品牌: R&D systems 型号: CDK002 规格: 1 KT R&D CDK002 CellXVivo Human Th2 Cell Differentiation Kit 产品编号 CDK002| rndsystems CellXVivo Human Th2 Cell Differentiation Kit 产品介绍 Kit Summary For the differentiation of Th2 cells from a preparation of naïve CD4+ T cells. Key Benefits ...
Tumor immune tolerance is a prevalent phenomenon in many types of cancer [25]. Clinically, α-PD-1 can block the interaction between the PD-1 receptor and its ligand PD-L1, which can shift the immune balance towards anti-tumor immunity. As we expected, tumor immune tolerance was also obser...