TFE3重排型肾细胞癌(TFE3-rearranged renal cell carcinomas,TFE3 rRCC)是一类少见的肾癌亚型,1986年被首次报道,由于患者X染色体上一区一带二亚带TFE3基因发生易位并形成融合基因,又被称为Xp11.2易位/TFE3基因融合相关性肾癌(Xp11.2 translocation renal cell carcinoma,Xp11.2 tRCC)。2004年WHO肾肿瘤分类中将其正...
基因名: TFE3 别名: TFEA,RCCP2,RCCX1,bHLHe33 基因ID: 7030 Chromosome:(GRCh37) X Start: 48886237 End: 48900990 Strand: 信号通路: TFE3 基因突变与药物关于我们 “基因医生”项目,可以为肿瘤患者提供全流程逐级的治疗方案与治疗手段。本项目创始科学家团队在基础医学研究领域拥有丰厚实战经验,以NGS及RNA...
Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network.The article discusses a Juvenile Renal Cell Carcinoma (RCC) network study on the effect of mammalian target of rapamycin (mTOR) and tyrosine kinase inhibitors on ...
We utilized human kidney organoids, or tubuloids, to engineer a tRCC model by expressing one of the most common MiT/TFE fusions, SFPQ-TFE3. Fusion-expressing tubuloids adopt a tRCC-like phenotype and gene expression signature in vitro and grow as clear cell RCC upon xenotransplantation in ...
Oudard et al., "Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network," Annals of Oncology, vol. 21, no. 9, pp. 1834-1838, 2010.Malouf GG, Camparo P, Oudard S, Schleiermacher G, Theodore C, Rustine A...
Oudard et al., "Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network," Annals of Oncology, vol. 21, no. 9, pp. 1834-1838, 2010.Malouf GG, Camparo P, Oudard S, Schleiermacher G, Theodore C, Rustine A...
7104 Targeted agents in metastatic Xp11 Translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC NetworkMaloufG.CamparoP.OudardS.SchleiermacherRustineA.TheodoreingentaconnectEuropean Journal of Cancer Supplement