TFE3重排型肾细胞癌(TFE3-rearranged renal cell carcinomas,TFE3 rRCC)是一类少见的肾癌亚型,1986年被首次报道,由于患者X染色体上一区一带二亚带TFE3基因发生易位并形成融合基因,又被称为Xp11.2易位/TFE3基因融合相关性肾癌(Xp11.2 translocation renal cell carcinoma,Xp11.2 tRCC)。2004年WHO肾肿瘤分类中将其正...
For each feature, the fold change is defined as the ratio of the median feature values between ccRCC and TFE3-RCC. 52 image features that show significant differences between TFE3-RCC and ccRCC are identified using the two-sided Mann–Whitney U test. Multiple comparison correction is performed...
(transcription factor binding to IGHM enhancer 3) 该基因编码一个包含转录因子的基本螺旋环螺旋结构域,该转录因子结合基因启动子中的mue3型e-box序列。编码蛋白促进转化生长因子β(tgfβ)信号转导下游基因的表达。该基因可能参与肾细胞癌和其他癌症的染色体易位,从而产生融合蛋白。易位伙伴包括prcc(乳头状肾细胞癌)...
Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network. Ann Oncol. 2010;21(9).Malouf GG, Camparo P, Oudard S et al (2010) Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma ...
Xp11 translocation renal cell carcinomas (RCC) are characterized by several different translocations involving the TFE3 gene. Tumors with different specific gene fusions may have different clinicopathologic manifestations. Only 3 RBM10-TFE3 RCCs have been reported to date. Here, we added 4 cases of...
患者无任何症状,因单位体检检出左肾占位,疑似错构瘤;后赴医院以 RCC收治入院,并行机器人辅助部分切除。出院后病理确诊为XP11.2tfe3肾癌,肿瘤细胞CD117(+),P504S(+),KI67(10%+);ck7(-),;后补充报告TFE3(+)。请问目前后面改如何继续治疗? 叶文鑫 2016-01-28 浙江省立同德医院泌尿外科 收治疾病: 前列腺癌...
Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network.The article discusses a Juvenile Renal Cell Carcinoma (RCC) network study on the effect of mammalian target of rapamycin (mTOR) and tyrosine kinase inhibitors on ...
Oudard et al., "Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network," Annals of Oncology, vol. 21, no. 9, pp. 1834-1838, 2010.Malouf GG, Camparo P, Oudard S, Schleiermacher G, Theodore C, Rustine A...
7104 Targeted agents in metastatic Xp11 Translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC NetworkMaloufG.CamparoP.OudardS.SchleiermacherRustineA.TheodoreingentaconnectEuropean Journal of Cancer Supplement
喜欢 0 阅读量: 29 摘要: Xp11 translocation renal cell carcinomas (RCC) are 展开 关键词: RBM10 TFE3 Xp11 translocation renal cell carcinoma 年份: 2017 收藏 引用 批量引用 报错 分享 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文。 请先登入 我们已与文献出版商建立了直接...