单因素和多因素Cox回归分析进一步表明,ASPSCR1-TFE3融合是接受一线ICI联合治疗患者PFS的独立预后因素(Figure 1E-F)。 ASPSCR1-TFE3 rRCC患者的客观缓解率显著高于其他TFE3-rRCC亚型的患者(Figure 1G)。在接受ICI联合治疗的患者中,ASPSCR1-TFE3融合患者的OS也高于其他融合类型患者,但差异未达到统计学显著。 此外...
探针ASPSCR1/TFE3融合基因t(X;17)探针(荧光原位杂交法)代码:F.01180-01管理类别:不作为医疗器械管理探针名称:GSP ASPSCR1 / GSP TFE3供货周期:一周 临床意义 腺泡状软组织肉瘤罕见,占软组织肉瘤的0.2%-0.9%。本瘤青少年多见(15-35岁)。好发于四肢深部软组织。瘤细胞呈PAS阳性。主要症状为缓慢生长的软组织...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ASPSCR1 and TFE3 genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion of ASPSCR1 –also known as TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9 or ASPCR1 –with...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ASPSCR1 and TFE3 genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion of ASPSCR1 –also known as TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9 or ASPCR1 –with...
The presence, hexamer assembly, and enzymatic function of the segregase enabled the transcriptional impact of ASPSCR1-TFE3. The two proteins co-distributed across chromatin genome-wide, associated with enhancers, indicated by flanking H3K27ac enrichment in human cell lines, human tumors, and ...
ASPSCR1/TFE3基因融合检测-分子病理-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR)、免疫组织化学(IHC)和荧光原
The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identify therapeutic
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