原名:Patients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma 译名:在TFE3重排肾细胞癌中,ICI联合治疗对ASPSCR1-TFE3融合患者的疗效更佳 期刊:Molecular Cancer IF:27.7 发表时间:2024 通讯作者:Zhenhua Liu,Hao Zeng,Guangxi Sun...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ASPSCR1 and TFE3 genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion of ASPSCR1 –also known as TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9 or ASPCR1 –with...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the humanASPSCR1andTFE3genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion ofASPSCR1– also known asTUG,ASPL,ASPS,RCC17,UBXD9,UBXN9orASPCR1– with theTFE3gene – als...
The fusion oncogene ASPSCR1‐TFE3 directs epigenetic‐induced autophagy in alveolar soft part sarcomaAltered metabolism is considered to be one of the new hallmarks of cancer. Autophagy is one major avenue of altered cancer metabolism, enabling cell survival under metabolic stress and promoting ...
The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identify therapeutic
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After histopathologic confirmation of ASPSCR1-TFE3 fusion-positive ASPS, negative margins were achieved with wide local excision. At 18 months post-surgery, she remains recurrence-free.doi:10.1016/j.epsc.2017.09.007Rhee, Daniel SDunkel, Ira J...
若想进一步了解该报道,可详细关注原文:Zhao M, Huang Y, Yin X, Xu J, Sun Y, Wang J. PEComa with ASPSCR1::TFE3 fusion: expanding the molecular genetic spectrum of TFE3-rearranged PEComa with an emphasis on overlap with alveolar soft part sarcoma. Histopathology. 2023 Nov 7. doi: 10.1111...
若想进一步了解该报道,可详细关注原文:Zhao M, Huang Y, Yin X, Xu J, Sun Y, Wang J. PEComa with ASPSCR1::TFE3 fusion: expanding the molecular genetic spectrum of TFE3-rearranged PEComa with an emphasis on overlap with alveolar soft part sarcoma. Histopathology. 2023 Nov 7. doi: 10.1111...
Aims: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3. Although diagnosis is ...