若想进一步了解该报道,可详细关注原文:Zhao M, Huang Y, Yin X, Xu J, Sun Y, Wang J. PEComa with ASPSCR1::TFE3 fusion: expanding the molecular genetic spectrum of TFE3-rearranged PEComa with an emphasis on overlap with alveolar soft part sarcoma. Histopathology. 2023 Nov 7. doi: 10.1111...
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为了明确其生物学行为及其与ASPS的确切关系,有必要对更多此类肿瘤进行进一步研究。 若想进一步了解该报道,可详细关注原文:Zhao M, Huang Y, Yin X, Xu J, Sun Y, Wang J. PEComa with ASPSCR1::TFE3 fusion: expanding the molecular genetic spectrum of TFE3-rearranged PEComa with an emphasis on overl...
The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identify therapeutic targets for these rare cancers. Here, pr...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ASPSCR1 and TFE3 genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion of ASPSCR1 –also known as TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9 or ASPCR1 –with...
Aims: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3. Although diagnosis is ...
The ASPSCR1-TFE3 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the humanASPSCR1andTFE3genes located on chromosome bands 17q25.3 and Xp11.23, respectively. Fusion ofASPSCR1– also known asTUG,ASPL,ASPS,RCC17,UBXD9,UBXN9orASPCR1– with theTFE3gene – als...
Aims: Mesenchymal neoplasms involving TFE3 gene fusions are diverse, mainly include alveolar soft part sarcoma (ASPS) that is characterised by ASPSCR1::TFE3 fusion, and a small subset of perivascular epithelioid cell tumours (PEComas) referred to as TFE3-rearranged PEComa, that most frequently...
After histopathologic confirmation of ASPSCR1-TFE3 fusion-positive ASPS, negative margins were achieved with wide local excision. At 18 months post-surgery, she remains recurrence-free.doi:10.1016/j.epsc.2017.09.007Rhee, Daniel SDunkel, Ira J...
ASPSCR1-TFE3 FUSIONTUMORS PECOMASNEOPLASMSDEFINESAims: Mesenchymal neoplasms involving TFE3 gene fusions are diverse, mainly include alveolar soft part sarcoma (ASPS) that is characterised by ASPSCR1::TFE3 fusion, and a small subset of perivascular epithelioid cell tumours (PEComas) referred to ...