Human hemoglobin is a tetrameric protein consisting of two alpha-like and two beta-like globin chains each forming a pocket containing the heme group for binding oxygen (David Gell, this issue). From:Blood Cells, Molecules, and Diseases,2018 ...
A protein-based peptide drug carrier derived from the tetramerization domain of the chimeric oncogenic protein Bcr/Abl of chronic myeloid leukemia. Peptides to be delivered are grafted to the N-terminal helical region of Bcr/Abl tetramer. To facilitate cellular uptake, an Arg-repeating hexapeptide ...
What tetrameric protein contains -globin, and why would this protein be produced in erythrocytes?Formed Elements of the Blood:Whole blood consists of the liquid portion (called plasma) and the formed element (the cells and cell fragments). There are three main type...
& Liang G. Rational Design of a Tetrameric Protein to Enhance Interactions between Self-Assembled Fibers Gives Molecular Hydrogels . Angewandte 1–5 (2012).Zhang, X. et al. Rational design of a tetrameric protein to enhance interactions between self-assembled fibers gives molecular hydrogels. ...
protein NMRR67 dihydrofolate reductase (R67 DHFR) is a plasmid-encoded enzyme that confers resistance to the antibacterial drug trimethoprim. R67 DHFR is a tetramer with a single active site that is unusual as both cofactor and substrate are recognized by symmetry-related residues. Such ...
With this in mind, we have studied the refolding kinetics of WT-TTR and its most common amyloidogenic variant V30M-TTR, monitoring changes in intrinsic tryptophan fluorescence at different urea and protein concentrations. Our results demonstrate that the in vitro refolding mechanisms of WT- and ...
Theresults described, together with those reported previously, point at a prominent role of tetrameric band 3 in ligand binding.Ž.Keywords: Band 3 protein; Band 4.1 protein; Heterologous association; Complex stoichiometry; Erythrocyte membrane; Analyticalultracentrifugation1. IntroductionThe erythrocyte ...
The heterotrimeric SecYEG complex cooperates with YidC to facilitate membrane protein insertion by an unknown mechanism. Here we show that YidC contacts the interior of the SecY channel resulting in a ligand-activated and voltage-dependent complex with d
3Altmetric Metrics Abstract Green fluorescent protein (GFP) has rapidly become a standard tool for investigating a variety of cellular activities, and has served as a model system for understanding spectral tuning in chromophoric proteins. Distant homologs of GFP in reef coral and anemone display two...
The protein had a corrected sedimentation coefficient of 5.4 S and a molecular weight of about 88,000. The absence of Bence Jones proteinuria is explained by the high molecular weight of the tetramer.Access through your organization Check access to the full text by signing in through your ...