Transthyretin is a tetrameric protein mainly produced by the liver, which transports vitamin A–retinol-binding protein and thyroxin.13 Instability of the TTR molecule and proteolytic cleavage leads to dissociation of the tetramer into dimers and monomers and subsequent monomer misfolding produce soluble...
Tetrameric and Dimeric [N⋅⋅⋅I+⋅⋅⋅N] Halogen-Bonded Supramolecular Cages Lotta Turunen, Dr. Anssi Peuronen, Samu Forsblom, Dr. Elina Kalenius, Dr. Manu Lahtinen, Prof. Kari Rissanen Pages: 11714-11718 First Published: 20 June 2017 My body is a cage: Applying the robust...
Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product skeletons. Studies of these enzymes are important because the knowledge of their catalytic functions, enzyme structures, and reaction mechanisms can be used to create non-natural enzymes...
select article E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells Research articleOpen access E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate ...
Cellular cAMP level is elevated once adenylyl cyclases (AC), which can convert ATP to cAMP, is activated by upstream proteins such as G protein-coupled receptors [11]. Then downstream events, including activation of protein kinases A (PKA) which is a heterotetramer consisting of two catalytic...
A New Method for D2O/H2O Exchange in Infrared Spectroscopy of Proteins Malferrari, Marco;Venturoli, Giovanni;Francia, Francesco;Mezzetti, Alberto 337-342 The V30M Amyloidogenic Mutation Decreases the Rate of Refolding Kinetics of the Tetrameric Protein Transthyretin ...
PDF1442 WORD495 HTML14488 Publishing Process of This Article Item Count Browse1520 Download2076 Aug 6, 2016 (publication date) through Apr 30, 2025 本文章的被引频次 被引频次 (279) 本文章的期刊信息 出版物名称 World Journal of Gastrointestinal Pharmacology and Therapeutics ...
The tetrameric protein transthyretin (TTR) transports the hormone thyroxine in plasma and cerebrospinal fluid. Certain point mutations of TTR, including the Val122Ile mutation investigated here, destabilize the tetramer leading to its dissociation, misfolding, aggregation, and the eventual buildup of am...
Further investigations under stress conditions of Insulin analogues revealed the capability of the method to separate higher order oligomeric (Trimeric, and Tetrameric) species alongside covalent dimeric species. Additionally, the method holds good in separating and sequencing protamine peptides used in ...
Although the majority of these techniques stimulate mature DCs before administration using TAA-derived proteins, TAA-derived peptides, or tumor lysates, DCs can be administered intratumorally without additional stimulation by antigens [57]. Among them, methods using antigen-derived peptides and ...