In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of carrier vesicles to their correct destination. Recent studies have revealed a large number of evolutionarily conserved proteins that may function in tethering ...
The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor 来自 国家科技图书文献中心 喜欢 0 阅读量: 90 作者:R García-Mata,E Sztul 摘要: The membrane-transport factor p115 interacts with diverse components of the membrane-transport machinery. It binds two...
EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of incoming endocytic vesicles before fusion with early endosomes. Because of the presence of complex endosomal pathways in polarized and nonpolarized cells, we have examined the distribution of EEA1 in diverse...
Tethering proteins mediate the initial recognition and attachment of membranes, whereas SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein complexes are considered as the core fusion engine. SNARE complexes provide mechanical energy to distort membranes and drive them ...
The increased biogenesis of LDs, achieved by overexpressing the interorganelle tethering protein Mdm1, coupled with the accelerated degradation of LDs through upregulated lipases, resulted in a 10.70-fold increase in total FAs production. Co-overexpression of Mdm1 and selected lipases significantly ...
In other cases, genes that aren't usually close to each other on the chromosome can suddenly be stitched together to produce a new oncogenic fusion protein. During chromothripsis, many such changes occur simultaneously, rather than gradually, thus accelerating cancer development or its resistance to...
Cellular immune response of adenoidal and tonsillar lymphocytes to the P6 outer membrane protein of non-typeable Haemophilus influenzae and its relation to... Cellular immune responses to the P6 outer membrane protein of non-typeable Haemophilus influenzae (NTHi) were determined in vitro by measurin...
Fig. 1: VAP-A extends from the membrane with increasing protein density. Full size image VAP-A is inserted in the ER membrane using a single C-terminal transmembrane helix (TM) and exposes its N-terminal globular domain of the MSP family to the cytoplasm. The MSP, which recognizes protein...
Tetherin is an interferon-induced protein whose expression blocks the release of HIV-1 and other enveloped viral particles. The underlying mechanism bywhic... D Perez-Caballero,T Zang,A Ebrahimi,... - 《Cell》 被引量: 836发表: 2009年 ...
The endoplasmic reticulum (ER) is the most extensive organelle of the eukaryotic cell and constitutes the major site of protein and lipid synthesis and regulation of intracellular Ca levels. To exert these functions properly, the ER network is shaped in structurally and functionally distinct domains ...