AP adaptor proteinARF ADP ribosylation factorBFA Brefeldin ACATCHR Complexes associated with tethering containing helical rodsThe Conserved Oligomeric Golgi (COG) complex, a multi-subunit vesicle tethering complex of the CATCHR (Complexes Associated with Tethering Containing Helical Rods) family, controls ...
In the second and third stages, tethering proteins on the transport vesicle and target membrane interact weakly bringing the membranes together. This allows vesicle-associated SNARE proteins and target membrane-associated SNARE proteins to form complexes. Subsequent conformational changes in the SNARE ...
This study focused on one of the major exosome markers22, CD63, which is a protein belonging to the tetraspanin family and was the first characterised member23. CD63 is commonly referred to as a lysosomal membrane protein but is also found on the cell surface23,24. Although the tetraspanin ...
Phosphorylation of the vesicle-tethering protein P115 by a casein kinase II-like enzyme is required for golgi reassembly from isolated mitotic fragments. J. Cell Biol. 150, 475–488 (2000). Article PubMed PubMed Central CAS Google Scholar Yoder, A. et al. Effects of microtubule modulators ...
(Red, Qa-SNARE family; Light green, Qbc-SNARE family; Blue, R-SNARE family; Brown, SM protein; Pink, Tethering protein; Yellow, other fusogenic protein). Vps45, Vacuolar protein sorting 45 homolog; GARP, Golgi-associated retrograde protein. b The working model of vesicle transport and ...
D. ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Dev. Cell 23, 1129–1140 (2012). Article CAS PubMed Google Scholar Salvador-Gallego, R., Hoyer, M. J. & Voeltz, G. K. SnapShot: functions of endoplasmic reticulum membrane contact sites. Cell 171, ...
Much less clear are the steps in-between formation and fusion of vesicles, and we therefore provide a much needed update of the latest findings about vesicle tethering. The interplay between Rab GTPases, golgin family coiled-coil tethers and the conserved oligomeric Golgi (COG) complex at the ...
Other effectors such as motor proteins, tethering factors and SNAREs (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) are involved in the coordination of Rabs-mediated vesicle transport from donor membrane budding toward acceptor membrane fusion [6–8]. Dysregulation in Rabs level ...
The BBSome complex is involved in the fusion as well as tethering of the cargo to the IFT for trafficking. This is mediated by the action of BBS3/ARL6. Figure 1B demonstrates the working model of the targeting of rhodopsin to the photoreceptor OS. First step in rhodopsin sorting involves...
other Rab family members, Rab 35 and Rab11 have also been found to regulate exosome secretion by interacting with GTPase-activating protein TBC1 domain family member 10A-C (TBC1D10A-C) (Hsu et al., 2010). Studies have shown that Rab35 regulates MVBs docking or tethering at the plasma ...