参考资料: https://www.fiercepharma.com/pharma/adaptimmune-scores-fda-nod-first-engineered-cell-therapy-solid-tumor https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.11548 https://www.onclive.com/view/fda-grants-accele...
参考资料: https://www.fiercepharma.com/pharma/adaptimmune-scores-fda-nod-first-engineered-cell-therapy-solid-tumor https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.11548 https://www.onclive.com/view/fda-grants-ac...
迈杰转化医学拥有丰富的细胞和基因治疗（Cell and Gene Therapy，CGT）临床研究经验，目前已支持50余项Ⅰ-Ⅲ期CGT临床试验项目，涵盖多个领域：单/双靶点CAR-T，CAR-NK，U-CART，TILs，StemCell，AAV，mRNA 疫苗，以及TCR-T。肿瘤类型包括了实体瘤和血液瘤，并涵盖热门及创新靶点，如Claudin18.2,BCMA, GPC3和CD7...
参考资料 [1]Zhang P,et al.Challenges and new technologies in adoptive cell therapy. J Hematol Oncol. 2023 Aug 18;16(1):97.https://jhoonline.biomedcentral.com/articles/10.1186/s13045-023-01492-8 [2]Fu C,et al.Three-Year Follow-up on Efficacy and Safety Results from Phase 1 Lummicar...
进行初步评估或申请国内外抗癌会诊，以寻求适合自己的个体化治疗方案。参考资料 [1]Borgers J S W,et al.Personalized, autologous neoantigen-specific T cell therapy in linkstatic melanoma: a phase 1 trial[J]. Nature Medicine, 2025: 1-13.https://www.nature.com/articles/s41591-024-03418-4 ...
1.Engineered TCR-T CellI mmunotherapy in Anticancer Precision Medicine: Pros and Cons. Front Immunol. 2021;12: 658753. 2. Evolution of CD8+ T Cell Receptor(TCR) Engineered Therapies for the Treatment of Cancer. Cells. 2021 Sep;10(9): 2379....
2.SCG Presented Preclinical Data in an Oral Presentation at ASGCT 2024 Highlighting Superior Tumor Inhibition of its Immunoswitch Armored HPV-TCR T Cell Therapy (SCG142) against HPV-associated Cancers-SCG Star Handset (scgcell.com)
TCR-T疗法是一种过继免疫细胞治疗(Adoptive Cell Transfer Therapy,ACT)。过继免疫细胞治疗是指从肿瘤患者体内分离免疫活性细胞,在体外进行扩增和功能鉴定,然后向患者回输,从而达到直接杀伤肿瘤或激发机体的免疫应答杀伤肿瘤细胞的目的。 TCR-T疗法通过转导嵌合抗原受体(融合抗原结合域及T细胞信号结构域)或者TCRα/β异二...
TCR-T(engineered T cell receptor-T cell，TCR-T)疗法是通过基因工程将特异性识别肿瘤抗原的TCR基因序列转移到T细胞中，使其获得介导免疫反应，以及特异性识别并杀死肿瘤细胞，从而达到治疗肿瘤的目的。TCR-T和CAR-T(嵌合抗原受体T细胞)疗法同属于过继性T细胞治疗方式，两者有何差异呢?CAR-T仅能识别肿瘤表面的抗原...
1. STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells | Cell Death & Disease (nature.com)2. Next-Generation TCR T-cell Therapy (ADP-A2M4CD8) Demonstrates Strong Efficacy in a Broad Range of Solid Tumors; Adaptimmune Presents Data Update from its SURPASS trial at ...