Solid tumorsThe engineering of immune cells to target cancer cells (cellular immunotherapy) has been an exciting area of development in recent years. One type of cellular therapy, T cell receptor (TCR) gene eng
7. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives. DOI：10.1126/sciadv.adf3700
非病毒基因递送技术的迅速发展,将有望实现更快速、更低成本地开发TCR-T疗法。 TCR-T疗法的挑战及优化 eMedClub 除了以上关键点之外,“TCR-engineered T cell therapy in solid tumors: State of the art and perspectives”一文中表示“...
[3] Baulu E, Gardet C, Chuvin N, et al.TCR-engineered T cell therapy in solid tumors: State of the art andperspectives. Sci Adv. 2023, 9(7):eadf3700.
and clinical application of tumor-specific neoantigens for TCR-T cells.” Molecular cancer vol. 22,1 141. 30 Aug. 2023.[2] Baulu, Estelle et al. “TCR-engineered T cell therapy in solid tumors: State of the art and perspectives.” Science advances vol. 9,7 (2023): eadf3700.
E. Baulu., et al. TCR-engineered T cell therapy in solid tumors: state of the art and perspectives. Sci. Adv. (2023) Wang X., et al. Antigen/HLA-agnostic strategies for Characterizing Tumor-responsive T cell r...
1. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives. DOI:10.1126/sciadv.adf3700 2.Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. DOI:10.1182/blood-2009-03-211714...
1. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives. DOI:10.1126/sciadv.adf3700 2.Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. DOI:10.1182/blood-2009-03-211714 ...
这种高通量、集中筛选和识别全基因组T淋巴靶抗原的新方法,可以用来识别T细胞能有效识别的抗原。将人全基因组靶抗原库导入含有颗粒酶报告系统的靶细胞,与表达TCR的T细胞共孵育后,可对TCR的靶抗原进行富集和鉴定。T-Scan可用于识别CD8+T细胞的功能性靶抗原,并可从大量记忆T细胞中重复检测靶抗原。它们具有在全基因组范围...
[1] Shafer P, Kelly LM, Hoyos V. Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects. Front Immunol. 2022;13:835762.[2] Baulu E, Gardet C, Chuvin N, Depil S. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives. ...