每日一学:TCR-T,即T细胞受体工程化T细胞疗法(T-cell receptor engineered T cell therapy)。TCR的作用是识别抗原。由两条不同肽链构成的异二聚体,由α、β两条肽链组成,每条肽链又可分为可变区(V区),恒定区(C区),跨膜区和胞质区等几部分;其特点是胞质区很短。TCR分子属于免疫球蛋白超家族,其抗原特异性存...
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react ...
One type of cellular therapy, T cell receptor (TCR) gene engineered therapy, has shown particular promise in solid tumors. Through use of a heterodimer to recognize intracellular tumor antigens presented through the major histocompatibility complex (MHC), TCR T cells are able to evoke a cytotoxic...
Journal for ImmunoTherapy of Cancer 2015, 3(Suppl 2):P159 http://www.immunotherapyofcancer.org/content/3/S2/P159 POSTER PRESENTATION Open Access Optimizing engineered TCR T cell therapy for synovial sarcoma Sandra D'Angelo1, Melinda Merchant2, Luca Melchiori3, Hua Zhang2, Lini Pandite4, Tom...
Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma (HCC) are urgently needed. The common cytokine receptor γ chain (γc) family cytokines such as IL-2, IL-7, IL-15 and IL-21 play fundamental roles in T cell development, differentiation and effecto...
Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate tumor regression, including complete and durable responses, in a range of solid cancers, most notably in melanoma. However, its wider application and efficacy has been restricted
"We are very delighted with the approval of Phase I/II clinical trial of our LioCyx™, the first engineered TCR-T cell therapy for treatment of liver cancer in Singapore. It is an utmost encouragement on the recognition of innovative thera...
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors ArticleOpen access06 June 2023 Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response ...
T cell receptor-engineered T cell therapyscreening strategycancer immunotherapyT cell receptor-engineered T (TCR-T) cell therapies are at the forefront of cancer immunotherapy, offering a transformative approach that significantly enhances the ability of T cells to recognize and eliminate cancer cells. ...
Tumor antigens are crucial targets for T-cell-based therapy to induce tumor-specific rejection. However, identifying pancreatic ductal adenocarcinoma (PDAC)-specific T-cell epitopes has been challenging. Using advanced mass spectrometry (MS) analysis, we previously identified cancer-associated, class I...