比如免疫系统中最强大的细胞毒性T淋巴细胞 (Cytotoxic T lymphocyte,Tc或CTL),也被称为杀伤性T淋巴细胞,通过与癌细胞表面抗原标记物的结合来特异性的识别并消除癌细胞。除了特异性识别外,其他免疫细胞如自然杀伤细胞(NK,Natural killer cel...
事实上,某些非经典途径在抗肿瘤免疫、免疫耐受和抗胞内感染中具有极其重要的作用。参与非经典途径的APC主要是树突状细胞(dendritic cell,DC)与巨噬细胞(macrophage,Mϕ)。 4、抗原递呈的生理意义 T细胞只能识别经过加工并被MHC分子递呈的肽。因此,抗原的加工和递呈是T细胞监视和识别非己抗原的前提。从某种意义上来...
Clone deletionEndotoxin toleranceMacrophageTCR repertoireBackground:Endotoxin tolerance (ET) is a protective mechanism in the process of sepsis, septic shock, and their sequelae including uncontrolled inflammation. Accumulating evidence has shown that peripheral T cells contribute to the induction of ET. ...
OncoImmunology. 2014;3(4):e28147. [10] Pan K, Farrukh H, Chittepu VCSR, Xu H, Pan CX, Zhu Z. CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy. J Exp Clin Cancer Res. 2022 Mar 31;41(1):119. [11] Zhao Y, Deng J, Rao S, Guo S, Shen J,...
业已提出各种策略,包括以细胞激素(例如白介素-2(interleukin-2,IL-2))来治疗。IL-2对各种免疫细胞种类有所影响,包括T细胞、B细胞、单核球(monocyte)、巨噬球(macrophage)、经淋巴激素活化的杀手细胞(lymphokine activated killer cell,LAK)与NK细胞[10,40]。
这些非经典途径与经典途径并存,使一种抗原可通过不同的途径被加工递呈,扩大免疫应答的范围。事实上,某些非经典途径在抗肿瘤免疫、免疫耐受和抗胞内感染中具有极其重要的作用。参与非经典途径的APC主要是树突状细胞(dendritic cell,DC)与巨噬细胞(macrophage,Mϕ)。
11.受试者骨髓功能符合下列要求(筛查前 14 天内未输血小板或红细胞,未使用血小板生成素[Thrombopoietin,TPO]、粒细胞集落刺 激因子 [Granulocyte Colony-Stimulating Factor ,G-CSF]、粒细胞巨噬细胞集落刺激因子[Granulocyte Macrophage Colo...
参考资料：[1]Chen, Yuanyuan et al. “EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion.” Journal for immunotherapy of cancer vol. 12,6 e008375. 17 Jun. 2024, doi:10.1136/jitc-2023-008375[2]ascopubs.org/doi/10.1200/JCO.2024.42...
CellRapeutics™ In Vivo Cell Engineering: One-stopin vivoT/B/NK cell and macrophage engineering services covering vectors construction to function verification. LEARN MORE SOLUTION NOVEL TECHNOLOGY Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technol...
macrophage-dependent pathologies. Indeed, TCRab expressing macrophages have been implicated in granuloma formation in tuberculosis [10]. Given this and the fact that macrophages play a central role in the pathogenesis and progression of atherosclerosis [18–20], we tested whether the novel macrophage-...