in creating the premetastatic niche in which circulating tumor cells settle and grow. Premetastatic niches are preferred metastatic sites in target organs where owing to a preconditioned microenvironment, metastatic tumor cells home, under the control of primary tumor-derived growth factors, chemotactic...
In summary, elucidating the roles of lncRNAs derived from macrophages in cancer progression offers new avenues for therapeutic strategies, significantly improving patient outcomes in the fight against the disease. Further research into the functional significance of these lncRNAs and the development of ...
Results In stromal rich CMS4 tumours, we observed an enhanced TNF-伪 signalling signature. MSCs were conditioned with inflammatory tumour cells secretome (iTCS), and we observed an increased expression of PD-L1 and CD47 by both RNA-seq and flow cytometry. Analysis of primary CRC patient tumours...
in creating the premetastatic niche in which circulating tumor cells settle and grow. Premetastatic niches are preferred metastatic sites in target organs where owing to a preconditioned microenvironment, metastatic tumor cells home, under the control of primary tumor-derived growth factors, chemotactic...
Macrophages and tumour stroma cells account for the main cellular components in the tumour microenvironment (TME). Current advancements in single-cell analysis have revolutionized our understanding of macrophage diversity and macrophage–stroma interacti
1b, c). Significantly, each subtype contained cells from a different tumor type, indicating that the clusters and expression states were largely consistent and did not represent patient-specific subpopulations or batch effects, although they do vary in their proportions across nine cancer types (...
Neutrophil recruitment in tumor lumenT cell interaction (IHC)TNF signaling; WNTImmune check points scRNA-seqmIHCNanoString GeoMx [31,33,34,42., 43., 44., 45.,83] Mouse Cxcl1/2/3/5/8, Ccl20, Ccl3l1, Il1rn, Il1b, G0s2, Inhba, Spp1 N/A CT26 s.c. CRC CT26 intrasplenic ...
Consequently, exosomal miR-106a-5p-induced M2 macrophages reciprocally enhance CRC liver metastasis. These findings contribute to the identification of a novel and specific biomarker for the prevention and treatment of CRC. Methods Patient samples and follow-up A total of 311 plasma samples, tumor ...
To validate the model predictions, we compared model composition and predicted flux with canonical characteristics of M1 and M2 macrophages, provided inTable 1. Additionally, though the general TAM-like phenotype is broadly linked to CRC patient prognosis, we can relate the metabolic characteristics pr...
Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) are incompletely characterized. Here, we identify TAM-derived factor