记忆T细胞分为中枢记忆T细胞(Centralmemory T cells,TCM),效应记忆T细胞(Effector memory T cells,TEM),组织驻留记忆T细胞(Residentmemory T cells,TRM),干细胞样记忆 T 细胞(Stem-likememory T cells,TSCM).其中,干细胞样记忆T细胞能够进行自我更新和增殖,并具有多向分化的特征,是近年肿瘤免疫治疗领域的研究热点...
Stem cell featuresT cell exhaustionTcf1Exhausted CD8 T (Tex) cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts. A stem cell-like Tex (Tex-stem) subset can self-renew and differentiate into terminally exhausted (Tex-term) cells. Here, we ...
R., Danilo, M., Pinschewer, D.D., Charmoy, M., and Held, W. (2023). Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection.Sci. Immunol.8, eadh3113.
近日,来自瑞士巴塞尔大学的Daniel D. Pinschewer团队等在Immunity杂志上合作发表了一篇题为The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+CD8+T cells in chronic viral infection的文章,他们...
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics analyses showed that Tcf1 recruited the gen
CD8+T cells. Intravenous vaccination (SNP-IV) induced a higher proportion of TCF1+PD-1+CD8+T cells as compared to subcutaneous immunization (SNP-SC). Single-cell RNA sequencing showed that SNP-IV induced stem-like genes (Tcf7,Slamf6,Xcl1) whereas SNP-SC enriched for effector genes (Gzmb...
本文利用小鼠模型证明了——肿瘤中存在一群TCF1+ T细胞亚群,PD-1治疗有效主要是通过促进该群细胞发生增殖活化后产生的抗肿瘤作用。 Title: An intra-tumoral niche maintains and differentiates stem-like CD8 Tcells Pubication Data: 2019/12/11 Journal: Nature ...
在NSCLC和ESCC患者中,PD1-TCF1+CD8+干细胞样记忆T细胞的高表达可能与良好的预后及免疫治疗疗效有关,并且在NSCLC中与肿瘤微环境内TLSs的形成密切相关。 关键词: 肿瘤微环境 / 预后 / 三级淋巴结构 / 干细胞样记忆T细胞 Abstract: Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory ...
Improved understanding of CD8+ T cell function during HIV infection is vital to designing an HIV cure. We have identified a subset of lymph node CD8+ T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection...
近日,美国埃默里大学国家灵长动物研究中心微生物与免疫学部Mirko Paiardini研究团队在Nature Immunology杂志发表了题为DistinctSIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence的研究文章。这项研究通过流式、质谱、scRNA...