最近,一项关于TCF-1、Treg和结肠癌的研究引起了广泛关注。这项研究发表在《nature immunology》上,为我们揭示了TCF-1在Treg细胞中的作用以及它与结肠癌的关系。🌟 研究亮点: 1. 构建了TCF-1条件性敲除鼠,实现了在Treg细胞中敲除TCF-1的目的。 2. 对flox和control鼠的肠系膜淋巴结中的Treg细胞进行分选,并进行...
通过对比具有缺失TCF-1 Treg细胞的肠息肉模型小鼠与具有正常TCF-1表达 Treg细胞的对照组肠息肉模型小鼠,研究人员发现,在直肠与小肠中,具有缺失TCF-1 Treg细胞的肠息肉模型小鼠的息肉/肿瘤数量与严重性都有明显的增加。 更为重要的是,研究人员发现在直肠癌病人组织【8】的Treg细胞中TCF-1的表达量要明显低于这些病人...
通过对比具有缺失TCF-1 Treg细胞的肠息肉模型小鼠与具有正常TCF-1表达 Treg细胞的对照组肠息肉模型小鼠,研究人员发现,在直肠与小肠中,具有缺失TCF-1 Treg细胞的肠息肉模型小鼠的息肉/肿瘤数量与严重性都有明显的增加。 更为重要的是,...
在TCF-1缺陷的Treg中,不论是TCF-1结合的还是TCF-1+Foxp3都结合的分子表达水平明显升高,这表明这些基因可能在Treg中受TCF-1调控(d),进一步用Chip-seq确认了染色质的开放程度(e)。 进一步通过流式确认表型发现Treg的激活表型增加(CD69、ICOS、PD-1、CD44等)(a),TCF-1的缺失...
TCF-1-deficient Treg-cells strongly suppressed T-cell proliferation and cytotoxicity, but were compromised in controlling CD4+ T-cell polarization and inflammation. In mice with polyposis, Treg cell-specific TCF-1 deficiency promoted tumor growth. Consistently, tumor-infiltrating Treg cells of ...
The transcription factor TCF-1 is essential for the development and function of regulatory T (Treg) cells; however, its function is poorly understood. Here, we show that TCF-1 primarily suppresses transcription of genes that are co-bound by Foxp3. Single-cell RNA-sequencing analysis identified ...
Adoptive transfer and antigen specific treg assessment Naive CD4+ T cells were isolated from CD45.1+Rag1−/−OT-II mice and 1×106 of these cells were injected i.v. into WT or Tcf7fl/flVavCre recipients. One day later, mice were provided with OVA at 4 mg/mL ad libitum in drinkin...
Authors - Liang Zhang View Article human WB Front Med (Lausanne) IL-7-Treated Periodontal Ligament Cells Regulate Local Immune Homeostasis by Modulating Treg/Th17 Cell Polarization. Authors - Xin-Yi Yu View ArticleSee more citationsProteintech North America (HQ) Proteintech Group, Inc 5500 Pearl ...
et al. TCF1 and LEF1 control Treg competitive survival and Tfr development to prevent autoimmune diseases. Cell Rep. 27, 3629–3645 (2019). Article CAS PubMed PubMed Central Google Scholar Crotty, S. T follicular helper cell biology: a decade of discovery and diseases. Immunity 50, 1132...
调节T细胞(regulatory T cells, Treg)是CD4 T细胞中一个特殊的亚群,其特异性的表达转录因子FOXP3。调节T 细胞的一个主要功能在于抑制来自其他免疫细胞过度的免疫反应【1】。近年来,越来越多的证据表明Treg是一个包括多个亚群的细胞类型,每个亚群都具有不同的转录因子表达,使得其获得类似于其他 CD4 T细胞亚群的特性,...