Cited in 17 publications. TCF1/TCF7 antibody for WB, IHC, ELISA and reacts with human, mouse.
Proteintech's Rabbit Recombinant TCF1/TCF7 antibody is validated in WB, Indirect ELISA and shows reactivity with human, mouse samples.
作者使用上述的Tcf7fl/flCD8αcre小鼠确定CD8+T细胞中的TCF-1缺失具有抑制肿瘤发展的效应。同样地，Tcf7fl/flTcrd creER小鼠也证实γδ T中的TCF-1缺失的保护作用。因此，无论在TCRβ+还是γδ T-IELs中，TCF-1均抑制其抗肿瘤作用。最后，作者在人样本中发现，相比于CD3+TCRδ−和CD3+TCRδ−CD8+细胞...
Proteintech's Rabbit Recombinant TCF1/TCF7 antibody is validated in Cytometric bead array, Indirect ELISA and shows reactivity with human samples.
•别名:Tcf7 •基因位置:染色体 14q21.3 •编码蛋白质:转录因子TCF1 结构与功能 TCF1基因编码的蛋白质是一种转录因子,属于T细胞特异性转录调节子家族。该转录因子包含一个高度保守的结构域,称为高迁移率群体(high mobility group, HMG)结构域。HMG结构域使得TCF1能够与DNA结合,并调控靶基因的转录。 TCF1蛋...
在 T细胞发育过程中最早表达的转录因子是TCF-1,这个蛋白被TCF7基因编码,在 T细胞发育的ETP阶段,被 NOTCH1信号通路上调之后,一直保持很高的表达水平,直到成熟的T细胞。TCF-1 是T细胞发育过程中的命运决定转录因子,可以决定T细胞的发育过程...
Monoclonal Antibody for studying TCF7. Validated for F. Highly specific and rigorously validated in-house, TCF1/TCF7 (C63D9) Rabbit Monoclonal Antibody (PE-Cy7® Conjugate) (CST #90511) is ready to ship.
Monoclonal Antibody for studying TCF7. Validated for ChIP, F, IF, IF, IHC, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, TCF1/TCF7 (C63D9) Rabbit Monoclonal Antibody (CST #2203) is ready to ship.
T Cell Factor 7 (TCF7)/TCF1 Feedback Controls Osteocalcin Signaling in Brown Adipocytes Independent of the Wnt/β-Catenin
瘤内干细胞样CD8+T细胞对于ICB反应至关重要，其效应依赖于T细胞因子1（TCF1；由Tcf7编码）的表达，研究表明消除CD8+T细胞中的Tcf7会限制ICB在癌症模型中的疗效【1】，表达TCF7的CD8+T细胞的频率与黑色素瘤患者对ICB的阳性反应相关【2】。然而，一些研究得到了不一致的结果，在接受ICB治疗的晚期透明细胞肾癌患者中...