在慢性免疫性疾病或者肿瘤中,激活的T细胞也会获得独特的表型,持续的抗原刺激会导致T细胞BCL6表达增加,产生Tfh样表型。与CD8不同的是,其抑制受体表达并不显著增加。新进的研究鉴定了一群干细胞样的CD8+T细胞(TPEX),其表达TCF1和BCL6以及C...
2015. LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol. doi: 10.1038/ni.3226.Choi YS, Gullicksrud JA, Xing S, Zeng Z, Shan Q, Li F, Love PE, Peng W, Xue H- H, Crotty S (2015) LEF-1 ...
Using a mouse model of GVHD and GVL following allo-HSCT, we were able to study all of the major T cell functions, as well as phenotype, clinical outcomes, and gene expression, in a single model. In this model, we transplanted CD8 T cells from either WT or TCF-1 cKO mice into irrad...
As a consequence, the development of T follicular regulatory (Tfr) cells, which are a subset of aTreg, is abolished in TCF1/LEF1-conditional knockout mice, leading to unrestrained T follicular helper (Tfh) and germinal center B cell responses. Thus, TCF1 and LEF1 act redundantly to ...
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 2015, Nature Immunology Developmental gene networks: A triathlon on the course to T cell identity 2014, Nature Reviews Immunology The transcriptional landscape of αβ T ...
(8)A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responsesJournal of Experimental MedicineJanuary 1, 2024Han Feng, Zixuan Zhao, Xiaohong Zhao, Xue Bai, Weiwei Fu, Liangtao Zheng, Boxi Kang, Xiaohu Wang, Zemin Zhang, Chen Dongfollowed byincu...
LEF1 and TCF1 orchestrate CD4 + TFH differentiation and the loss of either will impair CD4+ cell differentiation43 TCF1 and LEF1 also specify T cell lineage and β-selection in thymic differentiation31. However, unlike LEF1, TCF1 promotes the dif- ferentiation of the CD4 + TH2 subset ...
The transcription factor TCF-1, encoded by Tcf7, is critical in the development of both memory T cells and Tfh cells following viral infections. However, the role of TCF-1 in Trh cell development has not been investigated. Utilizing a Tcf7 fl/flCD4 Creconditional knockout mouse model in ...
Th1 cells and T follicular helper cells (Tfh cells), are generated early after viral infection. However, the molecular pathways that drive the differentiation of these two distinct subsets remain unclear. Here, we demonstrate that a molecular circuit involving TCF1, Blimp1, and IL-2 regulates ...
LEF-1 and TCF-1 coordinated TFH differentiation by two general mechanisms. First, they established the responsiveness of naïve CD4+ T cells to TFH signals. Second, they promoted early TFH differentiation via the multipronged approach of sustaining expression of IL-6Rα and gp130, enhancing ...