Tcf-1 gene silence suppresses downstream gene expression in CD4+ T cell from bone marrow of aplastic anemia patients[J]. Ann Hematol, 2012, 91(3): 353-358.Miao Zheng,Kai Zheng,Jianfeng Zhou,Hanying Sun,Lifang Huang,Wenli Liu.Tcf-1 gene silence suppresses downstream gene expression in CD4+...
TCF-1 and TCF-4 are the major transducers of Wnt signaling in the intestine and the oncogenic drivers of colon cancer. However, knock-out of the TCF1 gene leads to intestinal tumors while knockout of TCF-4 suppresses growth and maintenance of crypt stem cells. These phenotypes suggest that...
Figure: Tcf-1 stage-specifically regulates gene networks in both the DN1 and DN2–DN3 stages and controls the fates of early T cell precursors. 基于Tcf-1缺失导致T细胞发育过程中的高度异质性,该课题组使用单细胞测序技术...
Transcription factor 7 encoded by TCF7 is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The transcription factor 7 can bind an enhancer element and activate the CD
【7】ZengW,ChenG,KajigayaS,eta1.Geneexpressionprofilingin CD34cellstoidentifydifferencesbetweenaplasticanemia patientsandhealthyvolunteers[J].Blood,2004,103(1):325-332. 【8】PongraczJ,HareK,HarmanB,eta1.Thymicepithelialcells provideWntsignalstodevelopingthymocytes[J].EurJ ...
autoimmunity and cancer. Although it has mostly been associated with positive regulation of chromatin accessibility and gene expression, TCF-1 has the potential to reduce chromatin accessibility and thereby suppress gene expression. In addition, the binding of TCF-1 bends the DNA and affects the chro...
Total thymocyte numbers were reduced 2–5-fold at all ages. The results demonstrate that mature T lymphocytes do not depend on a functional Tcf-1gene. Tcf-1 is not required for the development of some extrathymic T-cell subsets. 展开 ...
Gene Symbol TCF1/TCF7 Gene ID (NCBI) 6932 ENSEMBL Gene ID ENSG00000081059 Conjugate Unconjugated Form Liquid Purification Method Protein A purification UNIPROT ID P36402 Storage Buffer PBS Only Storage Conditions Store at -80°C. The product is shipped with ice packs. Upon receipt, store it...
The fold change in percent of cells expressing the indicated gene in each cell type is proportional to the circle size. Adjusted-p-values > 0.01 are masked with gray color. (d) Expression changes of the most differentially expressed genes between APCΔ486 and control B6 Treg-cells. See ...
We cloned the Tcf-1 gene by subtractive hybridization and found it to be highly expressed in the thymus compared to the mRNA level in the spleen as expected. Since apoptosis occurs enormously in the thymus, we were interested in whether Tcf-1 gene expression could be regulated by such a ...