CLL患者的CD3+、CD4+和CD8+ T细胞亚群中TCF1+细胞的百分比 为了探讨TCF1在不同T细胞亚组中表达降低的情况,该研究随后检测了33例CLL患者的CD3+、CD3+CD4+和CD3+CD8+ T细胞亚群中TCF1+细胞的百分比,并将其与HIs进行比较(图7A)。结果表明,CLL患者TCF1+...
WT和TCF1 cKO OTI T细胞的增殖情况相当良好,当用高剂量的抗CD3+ 抗CD28刺激时,TCF1 cKO OTI T细胞显示略微加速的细胞积累(>6个细胞分裂)(图A)。WT和TCF1 cKO OTI T细胞均下调CD62L,上调CD44、PD-1和CD28的表达,而TCF1 cKO细胞中的PD-1和CD28的表达略微增加(相对于WT细胞)(图B)。 当使用低剂量的...
4. Reis Bernardo Sgarbi., Rogoz Aneta., Costa-Pinto Frederico Azevedo., Taniuchi Ichiro., Mucida Daniel.(2013). Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol, 14(3), 271-80. doi:10.1038/ni.2518 5. Liu Xindong.,...
Tcf_1mRNA在再障患者和正常人骨髓CIM+1r细胞中的表达. 结果Tcf_1mRNA在再障患者骨髓CD4T细胞中的表达水平显着高 于正常人(O.01),且重型再障患者骨髓CD4细胞中 的表达水平明显高于非重型再障患者(0.01).结论与正常人相 比,Tcf_1基因在再障患者骨髓CD4+1r细胞中表达上调, ...
研究人员使用IL-17A-GFP报告小鼠的CD4+T细胞进行体外分化,生成了Th17inf和 Th17hom细胞。与naive T细胞相比,Th17inf和Th17hom细胞中Tcf7和Axin2的mRNA表达均降低。然而,只有Th17hom细胞在静息阶段重新表达这两个基因,表明TCF1在维持Th17ho...
Xue. 2017. Tcf1 at the crossroads of CD4+ and CD8+ T cell identity. Front. Biol. 12:83-93. https://doi.org/10.1007/ s11515-017-1445-3Gullicksrud, J.A., Shan, Q. & Xue, H.-H. Tcf1 at the crossroads of CD4+ and CD8+ T cell identity. ...
1后,UUO肾脏中纤维蛋白沉积明显减少(p<0.001),fibronectin(p<0.001)和COL1A1(p<0.001)的表达明显减少.2.通过单细胞测序数据挖掘,发现纤维化肾脏中有TCF-1的表达主要定位于T淋巴细胞.进一步IF染色与多色流式细胞术确定UUO肾脏中高表达的TCF-1主要定位于CD4~+T细胞.CD4~+T细胞内条件性敲除TCF-1后,UUO肾脏纤维...
C. et al. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence CD4 in CD8+ T cells. Nat. Immunol. 15, 646–656 (2014). Article CAS PubMed PubMed Central Google Scholar Chopp, L. B. et al. An integrated epigenomic and...
Importantly, TCF-1 inhibited Notch signaling and consequently protected HEB from Notch-mediated proteasomal degradation. Thus, TCF-1 shifts nucleosomes and safeguards HEB, thereby enabling their cooperation in establishing the epigenetic and transcription profiles of CD4+CD8+ thymocytes....
TCF-1 was shown to activate expression of the Th2 transcription factor GATA-binding protein 3 (GATA3) and thus to promote the development of IL-4-producing Th2 cells independent of STAT6 signaling. In this study, we show that TCF-1 is down-regulated in human naive CD4+ T cells ...