研究人员使用IL-17A-GFP报告小鼠的CD4+T细胞进行体外分化,生成了Th17inf和 Th17hom细胞。与naive T细胞相比,Th17inf和Th17hom细胞中Tcf7和Axin2的mRNA表达均降低。然而,只有Th17hom细胞在静息阶段重新表达这两个基因,表明TCF1在维持Th17hom...
CLL患者的CD3+、CD4+和CD8+ T细胞亚群中TCF1+细胞的百分比 为了探讨TCF1在不同T细胞亚组中表达降低的情况,该研究随后检测了33例CLL患者的CD3+、CD3+CD4+和CD3+CD8+ T细胞亚群中TCF1+细胞的百分比,并将其与HIs进行比较(图7A)。结果表明,CLL患者TCF1+...
4. Reis Bernardo Sgarbi., Rogoz Aneta., Costa-Pinto Frederico Azevedo., Taniuchi Ichiro., Mucida Daniel.(2013). Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol, 14(3), 271-80. doi:10.1038/ni.2518 5. Liu Xindong.,...
Xue. 2017. Tcf1 at the crossroads of CD4+ and CD8+ T cell identity. Front. Biol. 12:83-93. https://doi.org/10.1007/ s11515-017-1445-3Gullicksrud, J.A., Shan, Q. & Xue, H.-H. Tcf1 at the crossroads of CD4+ and CD8+ T cell identity. ...
1、研究揭示了在免疫原性较低的肿瘤中,免疫治疗患者对免疫检查点抑制剂(ICB)的响应与CD8+T细胞中的TCF1表达密切相关,TCF1表达是必不可少的,而在免疫原性较高的肿瘤中则不需要;2、在TCF1缺乏的情况下,低抗原表达肿瘤中的免疫检查点抑制剂(ICB)治疗反应可以通过使用癌症疫苗来提升。
C. et al. TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence CD4 in CD8+ T cells. Nat. Immunol. 15, 646–656 (2014). Article CAS PubMed PubMed Central Google Scholar Chopp, L. B. et al. An integrated epigenomic and...
(2018). TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. Nature immunology, 19(12), 1289-1299. [3] Yu, Q., et al. (2012). The TCF-1 and LEF-1 transcription factors have cooperative and ...
其次,免疫荧光证实相比于TCF-CD8+T细胞,更多的TCF1+CD39+CD8+TM定位于B淋巴滤泡区,且与病毒RNA+CD4+靶细胞距离更近,表明TCF1+CD39+CD8+TM细胞具有更好的能力与感染CD4+靶细胞相遇以控制病毒。最后,作者在人HIV淋巴结样本中同样检测到TCF1+CD39+CD8+T细胞的存在。虽然低表达GzmB,但抗原刺激同样诱导脱颗粒和...
Tcf1 at the crossroads of CD4+ and CD8+ T cell identity. Front. Biol. 12, 83–93 (2017). Article CAS Google Scholar Xing, S. et al. Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat. Immunol. 17, 695–703 (2016). Article...
Instead, TCF-1 physically interacted with Runx3 to cooperatively silence Cd4. Thus, TCF-1 and LEF-1 adopted distinct genetic 'wiring' to promote the CD4+ T cell fate and establish CD8+ T cell identity.This is a preview of subscription content, log in via an institution to check access. ...