Creating a mouse model that recapitulates human tau pathology is essential for developing strategies to intervene in tau-induced neurodegeneration. However, mimicking the pathological features seen in human pathology often involves a trade-off with artificial effects such as unexpected gene insertion and ...
Tau vaccines given as nasal drops induced tissue tau-immunoreactive antibody production and ameliorated cognitive impairment in FTLD-tau model mice. In vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis, and neuronal loss...
We next sought to determine if the effect of retromer depletion on the levels of truncated human Tau was reproducible in an independent human Tau model system. To do this, we utilized a mouse cortical neuron cell line that enables the inducible expression of human Tau50 (Supplementary Fig. 3c...
8, 9, 10 To better understand the development of motor impairment in tauopathies, we have analyzed the age-dependent expression of mutant tau and the age-dependent innervation status of the neuromuscular junction in the Tg30tau transgenic model. Tg30tau transgenic mice express a human tau protein...
A zebrafish Tauopathy model might allow chemical and genetic screens to isolate novel treatment approaches. Structural and biochemical conservation suggest that the zebrafish CNS is an appropriate setting to model disease. Transgenic zebrafish expressing human Tau show features of human Tauopathy....
(KA), widely used experimentally to induce a model of acquired epilepsy, has been shown to decrease the tau phosphorylation initially, and then increase and sustain thehyperphosphorylationof tau in thehippocampus(Liang et al., 2009; Liu et al., 2016; Mazanetz and Fischer, 2007; Palop and ...
Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study Age-related decline in white matter integrity in a mouse model of tau- opathy: an in vivo diffusion tensor magnetic resonance imaging study. Neuro- ... N...
Fig. 3: Microglial REV-ERBα KO exacerbates tauopathy in males only in an AAV-tau P301L model.a Schematic depicting post-natal P0 intracerebroventricular (i.c.v.) injection of AAV-tau P301L into Cx3cr1::CreERT2+;Nr1d1fl/fl
To understand the correlation between these pathological hallmarks and functional deficits, we assessed behavioral and physiological deficits in the PS19 mouse model, a broadly utilized model of tauopathy. At 9 months, PS19 mice have characteristic hyperactive behavior, a decline in motor strength, ...
elegans , making it an excellent model in which to study their pathogenesis. In this article, we review some of the important findings gained from C. elegans tauopathy models.-Pir, G. J., Choudhary, B., Mandelkow, E. Caenorhabditis elegans models of tauopathy. 展开 关键词:...