GFAP Upregulation by Astrocytes May Attenuate Phospho-Tau Levels in a Tauopathy Mouse ModelBackground Astrocytes react to amyloid-β plaques and phospho-tau (pTau) neurofibrillary tangles in the Alzheimer's disease brain but their net effect on these Alzheimer's neuropathological hallmarks remains ...
We next profiled microglial transcriptional changes in a tauopathy mouse model of isolated microglia from 11-month-old PS19 mice. Disease-associated microglia (DAM) are identified as a subset of microglia associated with AD and other neurodegenerative diseases with a unique transcriptional signature34...
et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337–351 (2007) Article CAS Google Scholar Simonovitch, S. et al. Impaired autophagy in APOE4 astrocytes. J. Alzheimers Dis. 51, 915–927 (2016) Article CAS Google Scholar ...
Acta Neuropathologica Communications (2023) 11:5 https://doi.org/10.1186/s40478-022-01489-3 Acta Neuropathologica Communications RESEARCH Open Access Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy L. Arouche‑Delaperche1*† , ...
Tauopathy in the APPswe/PS1{Delta}E9 mouse model of familial Alzheimer's disease Background Alzheimer's disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk f... A Metaxas,C Thygesen,SJ Kempf,... 被引量: 0...
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53:337-351Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido ...
Protein degradation impairment and synapse elimination by microglia in BSN P3866A knock‐in mouse model of tauopathy doi:10.1002/alz.090096Alzheimer's & Dementia: The Journal of the Alzheimer's AssociationPatel, HenikaMartinez, PabloLopes, DaniellaJury, NurVanderbosch, KatieYou, Yanw...
The current study demonstrates that TREM2 deficiency leads to worsened tau pathology, altered microglial reactivity, and robust signaling abnormalities in the hTau mouse model of tauopathy. These findings have direct implications for the role(s) of TREM2 in the clearance and/or propagation of tau...
Importantly, NMNAT neuroprotection was also confirmed in a mouse model of tauopathy, where NMNAT2 was downregulated in both cortex and hippocampus of mice overexpressing the FTDP-17 associated mutant tau P301L. In this model, hippocampal-specific overexpression of either NMNAT1or NMNAT2 ...
P2‐066: INNATE IMMUNITY STIMULATION VIA TOLL‐LIKE RECEPTOR 9 IN A TAUOPATHY MOUSE MODEL, RTG4510doi:10.1016/j.jalz.2018.06.751HenrietaNewScholtzovaNewAkashNewG.NewPatelNewHelenNewKeizhenNewLyoNewElizabethNewL.NewAlzheimer's & Dementia