The mechanism by which this common variability in the tau gene influences the development of these neurodegenerative diseases is unclear; however, it further suggests a central role for tau in the pathogenesis o
and Hutton M. (2001) Molecular genetics and transgenic modeling of the tauopathies in Alzheimer's disease, in Advances in Etiology, Pathogenesis and Therapeutics (Iqbal K., Sisodia S. S., Winblad B., eds), pp. 71-85. Jon Wiley & Sons, Chichester....
The mechanism by which this common variability in the tau gene influences the development of PSP is unclear; however, it further suggests a central role for tau in the pathogenesis of several neurodegenerative conditions including Alzheimer's disease (AD)....
Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating activity of specific protein aggregates. In tauopathies, including Alzheimer’s disease (AD), tau protein abnormally accumulates and induces dysfunction of the affect
The precursor protein of non-Aβ component of Alzheimer’s disease amyloid is a presynaptic protein of the central nervous system. Neuron 14, 467–475 (1995). Article PubMed CAS Google Scholar Lewandowski, N. M. et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. ...
Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's disease and related tauopathies, and the discovery that mutations in the tau gene cause frontotemporal dementia, much effort has been directed towards determi
Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's disease and related tauopathies, and the discovery that mutations in the tau gene cause frontotemporal dementia, much effort has been directed towards determi
challenges to designing effective apoE-targeted therapeutic strategies. This review examines the key pathobiological pathways of apoE and related targeting strategies with a specific focus on the latest technological advances and tools. The pathogenesis of Alzheimer disease...
The pathogenesis of Alzheimer disease Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–80% of all dementia cases [1]. Despite the broad prevalence and rising incidence of AD, there are only six FDA-approved drugs currently used to treat symptoms...
Here we review the findings that have helped in assigning a possible function to specific SARs and adaptor proteins in aggrephagy in the context of proteinopathies, and also highlight the interplay between aggrephagy and the pathogenesis of proteinopathies. Graphical abstract Download: Download high-...