Tauopathies are a group of over 20 clinicopathological neurodegenerative diseases includingAlzheimer's disease(AD), the most common type of dementia,progressive supranuclear palsy,Pick's disease,corticobasal degeneration, among others. Tauopathies are defined byneurodegenerationand the presence of tau aggregat...
Tauopathies are a group of neurodegenerative diseases such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), or frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) that are characterised by altered ...
Tauopathy refers to a group of neurodegenerative diseases with pathological inclusions containing fibrillar aggregates of tau proteins. Although the tauopathies comprise a diverse phenotypic group, filamentous neuronal or neuronal and glial tau inclusions associated with the degeneration of affected brain regi...
The fruit fly Drosophila melanogaster has emerged in the past decade as an excellent model for neurodegenerative diseases. Drosophila models of tauopathy display prominent features of the human disease, including compromised lifespan; impairments of learning, memory, and locomotor functions; and age-...
Increasing evidence supports that defects in RNA processing cause neurodegenerative diseases,including tauopathy and TDP-43 proteinopathy.Tauopathy is characterized by the presence of tau-positive protein aggregates in the affected brain regions.In tauopathy patients,a large number of mutations have been...
作者: S Musil 摘要: Tauopathy refers to a group of neurodegenerative diseases with pathological inclusions containing fibrillar aggregates of tau proteins. Although the tauopathies comprise a diverse phenotypic group,... DOI: 10.1007/978-0-387-79948-3_512 年份: 2011 收藏...
The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tauopathy in animal model...
Microglia activation in neurodegenerative diseases can have both beneficial and detrimental effects. Similarly, in response to tauopathy, some of the microglial responses are adaptive, serving protective functions, while others could be maladaptive and promote toxicity. Inhibiting microglial NF-κB activity...
Intracellular tau inclusions, a hallmark of several neurodegenerative diseases, propagate in the brain in an unknown fashion. Brain extracts prepared from mice expressing mutated human tau injected into mice expressing wild-type human tau induce the form
Tauopathies are a group of neurodegenerative diseases characterized by brain deposition of neurofibrillary tangles (NFTs) of tau protein (the microtubule-associated protein tau). NFTs are fundamental to both primary tauopathies, such as frontotemporal lobar degeneration (FTLD), and secondary tauopathies, ...