The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer’s disease (AD). They project broadly throughout the brain’s white matter. We investigated the relationship between IdC microstruc
Tauopathy is a common hallmark of many neurodegenerative diseases, including Alzheimer’s disease, corticobasal degeneration and frontotemporal dementia (FTD) with Parkinsonism [[1], [2], [3], [4], [5]]. It is characterized by the aggregation of misfolded and hyperphosphorylated tau protein in...
Apoptosis in transgenic mice expressing the P301L mutated form of human tau. The rTg4510 mouse is a tauopathy model, characterized by massive neurodegeneration in Alzheimer's disease (AD)-relevant cortical and limbic structures, def... RM Ramalho,Viana, Ricardo J. S.,RE Castro,... - 《Mol...
Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that reducing acetylated tau by pharmacologically inhibiting p300-mediated tau acetylation at lysine 174 red...
Tauopathies are a class of neurodegenerative diseases characterized by the presence of aggregates of abnormally hyperphosphorylated forms of the microtubule-associated protein tau (MAPT) in nerve cells and/or glial cells.1 Tauopathies include Alzheimer disease, some forms of frontotemporal lobar degeneratio...
S Humez1,2, CE Müller5, LV Lopes4, L Buée1,2,10 and D Blum1,2,10 Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models...
Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer’s disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models. However, the impact of selective A
Is intractable epilepsy a tauopathy? Zhi-Qin Xia, Xue-Feng Wanga,⇑, Xiao-Fang Shub, Guo-Jun Chena, Fei Xiaoa, Ji-Jun Suna, Xi Zhua aDepartment of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China bDepartment of Gynaecology and Obstetrics, Central Hosp...
(αS) abnormalities in PDD and DLB pathogenesis. However, it is currently unknown how αS abnormalities contribute to memory loss, particularly since forebrain neuronal loss in PDD and DLB is less severe than in Alzheimer’s disease. Previously, we found that familial Parkinson’s disease-linked...
Most Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (p-tau). LATE-NC