[1] Tara E. Tau interactome mapsand mitochondrial processes associated with neurodegeneration.Cell (2020) Doi: https://doi.org/10.1016/.2021.12.041 [2] New findings for the function of tau in neurodegenerative disease. Retrieved Jan. 20, 2022 from https://www.eurekalert.org/news-releases/940...
[1] Tara E. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell (2020) Doi: https://doi.org/10.1016/j.cell.2021.12.041 [2] New findings for the function of tau in neurodegenerative disease. Retrieved Jan. 20, 2022 from https://www.eurekalert.org...
In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain. In the previous year, a paired helical filament (PHF) protein had been identified in neurofibrillary tangles in the brains of individuals with Alzheimer disease (AD), but it was not until 1986 that th...
[1] Tara E. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell (2020) Doi: https://doi.org/10.1016/j.cell.2021.12.041 [2] New findings for the function of tau in neurodegenerative disease. Retrieved Jan. 20, 2022 from https://www.eurekalert.org...
How pathological tau — a feature of several neurodegenerative diseases — affects neuronal network function is not clear. The authors took electrophysiological recordings of the activity of frontal cortex pyramidal neurons in mice with forebrain expression of human mutant tau, before the animals ...
4. Chen, H. and D.C. Chan, Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet, 2009. 18(R2): p. R169-76. 5. David DC, Hauptmann S, Scherping I, Sch...
6 Collinge, J. Mammalian prions and their wider relevance in neurodegenerative diseases.Nature539, 217 (2016). 7 Fitzpatrick, A. W. et al. Cryo-EM structures of tau filaments from Alzheimer’s disease.Nature547, 185 (2017). BioArt,一心关注生命科学,只为分享更多有种、有趣、有料的信息。关注...
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduce tau
1.Peng C, Trojanowski JQ, Lee VM: Protein transmission in neurodegenerative disease. Nat Rev Neurol 2020, 16(4):199-212. 2.Wilson DM, 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I: Hallmarks of neurodegenerative diseases. Cell 2023, 186(4):693-714. ...
[1] van Dyck, C.H., et al. Lecanemab in Early Alzheimer's Disease[J]. N Engl J Med, 2023, 388(1): 9-21. [2] Sims, J.R., et al. Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial[J]. Jama, 2023, 330(6): 512-527. ...