英文名称: TAS2R14 agonist-2 总访问: 55 国产/进口: 进口 半年访问: 11 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg 最后更新: 2025-2-13 货号: HY-153265 CAS 号: 2883007-69-8 参考报价: 2695; 2450; 3900; 8200 立即询价 电话咨询 ...
TAS2R14 agonist-2 CAS No. : 2883007-69-8 MCE 站:TAS2R14 agonist-2 产品活性:TAS2R14 agonist-2 (compound 28.1) 是一种有效的选择性 TAS2R14 抑制剂,EC50 值为72 nM。 研究领域:Others 作用靶点:Others 相关产品:Antitumor agent-67 | Catechin 7-O-β-D-glucopyranoside | Carbobenzoxyproline...
Bitter taste receptor-14 (TAS2R14) is a GPCR also expressed on human airway smooth muscle cells, which signals to intracellular [Ca ], resulting in relaxation of the airway, and is a novel target for bronchodilators. Here, we examine long-term, agonist-promoted down-regulation of TAS2R14...
et al. Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist. Cell Res 34, 735–738 (2024). https://doi.org/10.1038/s41422-024-00995-4 Download citation Received06 May 2024 Accepted23 June 2024 Published05 July 2024 Issue DateOctober 2024 DOIhttps://...
The compound identified was also compared to conventional 尾-agonist (isoproterenol and salbutamol) for efficacy in reducing cell stiffness of cultured ASMCs and airway resistance of ovalbumin-treated mice. Results: BitterDB analysis found 18 compounds activating TAS2R5, 10, and 14 at < 100 渭M ...
Saikosaponin b (SSb) was confirmed for the first time to be a specific agonist of TAS2R14 and had an EC50 value of 4.9渭M. A molecular docking study showed that SSb could directly bind to a TAS2R14 model through H-bond interactions with Arg160, Ser170 and Glu259. Moreover, SSb ...
Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonistCell signallingCryoelectron microscopydoi:10.1038/s41422-024-00995-4Lele TaoDongxue WangQingning YuanFenghui ZhaoYu ZhangTianyuan DuShiyi ShenH. Eric Xu
Moreover, we identified a natural agonist of TAS2R7 and TAS2R14 for further studies on the role of bitter receptors in satiety control and food intake.LeMolecularNevéMolecularBorisMolecularFoltzMolecularMartinMolecularDanielMolecularHanneloreMolecular...