Here we show that the gut microbiome downregulates PD-L2 expression and its binding partner repulsive guidance moleculeb (RGMb) to promote anti-tumour immunity and identify bacterial species that mediate this effect. PD-L1 and PD-L2 share PD-1 as a binding partner, but PD-L2 can also bind ...
Heme oxygenase-1 (HO-1) facilitates the breakdown of heme, leading to the liberation of unbound iron and the onset of ferroptosis. In NSCLC, the lncRNA RGMB-AS1 interacts with HO-1, increasing its stability and potentiating ferroptosis by impeding ubiquitination mediated by the E3 ligase TRC8....
PD-L2 binds to PD-1 with an approximately three-fold higher affinity than does PD-L1, and, like PD-L1, sends an inhibitory signal which attenuates T-cell function [84]. PD-L2 also binds to the repulsive guidance molecule b (RGMb) to mediate immunotolerance in the lung [85,86]. A ...