The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to investigate whether the organ of Corti could be a target tissue for insulin signaling using auditory House Ear Institute-Organ of Corti 1 (HEI-OC1) cells as ...
Although the target tissue of each disease differs, being the synovial membrane of the joints in RA and the cells of the central nervous system in MS, there are many common features shared between the two (for an extended review on RA pathogenesis, see [78] and for MS, see [79]). Fir...
Several publications have demonstrated that the overexpression of GLUT4 in mouse adipose tissue alone does not reduce the insulin intolerance induced by a high‐fat diet.3, 4 Translocation of GLUT12, however, might be an alternative mechanism—and therefore an attractive target for diabetes therapies...
Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma Yinyin Xue Yue Wang Ker Yu ResearchOpen Access10 Dec 2024Oncogene P: 1-14 Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM ...
Insulin response of a hybrid amylase/CAT gene in transgenic mice The analysis of the amylase promoter, however, has demonstrated, besides tissue and cell specificity, elements responsive to cellular stimulation by insulin and diet =-=[17, 21]-=-. Analysis of promotor/enhancer elements in conjunct...
Chronic hypoxia, inflammation, and fibrotic tissue remodeling are tightly interwoven processes. Cells of the PT are especially vulnerable to stress due to their immense energy consumption required for the reabsorption of filtered molecules and ions. Thus, it is not surprising that these cells are the...
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance rriba, J., Veyrat-Durebex, C., Rohner- Jeanrenaud, F., Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance. ... AL Poher,J Altirriba,C Veyrat-Durebex,... - ...
hydrogels and tissue scaffolds, research has been driven to fuseimmunosuppressionand biomaterial delivery mechanism ofislet transplantationtogether. In Korea, researchers demonstrated the use of an injectable hydrogel as a delivery mechanism for isletxenograftand immunosuppressant FK506 andclodronateliposomes, ...
The olfactory epithelium is the only neuronal tissue capable of generating new neurons during adult life and hence must express genes responsible for this ... O Bernard,S Ganiatsas,G Kannourakis,... - 《Cell Growth Diff》 被引量: 197发表: 1994年 The Insulin-like Growth Factor Signaling Pat...
et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat. Med. 15, 1082–1087 (2009). CAS PubMed Google Scholar Fitzner, B. et al. Senescence determines the fate of activated rat pancreatic stellate cells. J. Cell. Mol. Med. 16, 2620–2630 (2012)...