By definition, a hormone is a substance that is produced and released by one organ or tissue and is transported via the blood to a remote target organ or tissue where it causes a physiological response. From: Equine Exercise Physiology, 2008 ...
Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes Rev. 2009;10(6):660–70.Macciò A, Madeddu C, Mantovani G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. ...
Similar results were observed for the respective global strain rates (data not shown). According our empa study design (Fig. 3A), we investigated the effects of empa on the cardiac target-organ damage in the hypertensive diabetic rats (mRen27/tetO-shIR). The survival rates (Fig. 3B) ...
Furthermore, there has also been a focus on the emerging concept of regulation of RAS, such as receptor-interacting proteins and receptor modifications, in the new discovery of therapeutic agents for tissue protection. The RAS has a pivotal role in various target organ damage, with complicated ...
This iron deposition in tissues has been linked to various diseases and organ degeneration, affecting areas like bones, the brain, and the kidneys [25, 26]. However, the mechanisms through which excess iron damages chondrocytes under OA pathogenic conditions remain poorly understood. In the current...
Sirolimusis used for the prevention of organ rejection in kidney allograft recipients (initially in combination withciclosporinand a corticosteroid and then with a corticosteroid only). Mode of Administration Oral. Pharmacological Effects Sirolimus binds to theimmunophilin, FK-binding protein-12 (FKBP-12...
(TAG) accumulation. Potential sources contributing to the hepatic fatty acid pool for TAG synthesis include (1) dietary fatty acids taken up in the form of chylomicron remnants from the small intestine; (2) the plasma FFA pool comprising those derived from lipolysis of adipose tissue as well ...
but CT and MRI scans suggest that poisonous changes occur in the brain,including the abnormal buildup of proteins called amyloid plaques and tau tangles.The damage starts in the parts of the brain essential for forming memories but then spreads throughout the organ,with brain...
Visceral adipose tissue (VAT) encases mesenteric lymphatic vessels and lymph nodes through which lymph is transported from the intestine and mesentery. Whether mesenteric lymphatics contribute to adipose tissue inflammation and metabolism and insulin resistance is unclear. Here we show that obesity is ...
The muteins of the invention may also be conjugated with any suitable therapeutically active agent, e.g., for the targeted delivery of such agents to a given cell, tissue or organ or for the selective targeting of cells, e.g., of tumor cells without affecting the surrounding normal cells....