Target cellsFollowing Yalow and Berson's basic research on the binding of polvpeptide hormones to plasma proteins, an integrated picture of hormone-receptor interaction and biological activity has been proposed for insulin in experimental models and in man. The extracellular interaction of the insulin...
Furthermore, internalization appears to be a requirement for efficient degradation of insulin since the vast majority (perhaps all in certain cells) of the degrading activity is intracellular. Internalization may not be required to produce certain actions of the hormone, however, and the two ...
Recently, gut K cells have been shown to express glucokinase, the glucose sensor of pancreatic β cells, and transgenic mice expressing human insulin under the control of a K cell-specific promoter are resistant to diabetes development induced by the β-cell toxin streptozotocin. These novel findin...
Furthermore, internalization appears to be a requirement for efficient degradation of insulin since the vast majority (perhaps all in certain cells) of the degrading activity is intracellular. Internalization may not be required to produce certain actions of the hormone, however, and the two ...
B Destruction of beta-cellsC Reduced in number or lack of insulin receptors on target cells D Deficiency of secretions from Islet of Langerhans Video Solution Play VideoText SolutionVerified by Experts The correct Answer is:C 1| ShareSave Answer Step by step video & image solution for NIDDM is...
insulin (1 U/kg bw) or saline and after 4 h refeeding. Mouse hepatocytes were isolated as described elsewhere38. Primary hepatocytes were cultured on matrigel-coated six-well plates in Williams E media (Sigma) supplemented with 10% FBS. 1.5−2.5×106cells were allowed to adhere for 2...
Examines the activation of Reg gene for insulin-producing islet beta cell regeneration. Importance of pancreatic islet beta cells regeneration in diabetes ... Akiyama,Takako,Takasawa,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 69发表: 2001年...
reported that CHIP expression is upregulated in the postmortem brain tissues of patients after stroke31, implying that CHIP may play an important role in the pathological mechanism after stroke and may be a potential therapeutic target for neuronal injury. In our study, CHIP protected N2a cells ...
Research focusing on the insulin-inhibitory receptor, known as inceptor, has revealed promising paths for protecting beta cells, providing optimism for therapy that directly addresses diabetes. A groundbreaking study involving mice with obesity caused by diet shows that eliminating inceptor improves glucose...
The decreased percentage of E-rosette-forming cells (range, 21 to 77 per cen... Z Fuks,S Strober,Kaplan HS - 《New England Journal of Medicine》 被引量: 180发表: 1976年 Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding ...