C. et al. Inhibition of complement activity by humanized anti C5 antibody and single-chain Fv. Mol. Immunol. 33, 1389–1140 (1996). Article CAS PubMed Google Scholar Adis International Limited Eculizumab: 5G1.1, h5G1.1, long-acting anti C5 monoclonal antibody 5G1 1, long-acting anti C5...
The advent of CRISPR-Cas9 as an RNA-guided site-specific DNA endonuclease facilitates genome modification in a precise and efficient way and brings a new dawn to targeted gene therapy.3,4However, this genome editing tool has suffered from controversy due to its off-target effects. In 2016, ba...
In recent years, multi-target drugs - that is, drugs that affect more than one gene or protein - have been moving into the focus of drug discovery and development [1, 2]. The first reason for this phenomenon is that multi-target drugs have been found to be more effective than single-...
Phage therapy: A step forward in the fight against antibiotic resistance 8 January 2025 | By Drug Target Review A new study shows how phages, viruses that kill bacteria, can coexist on a single bacterial strain. This offers valuable insights for developing more effective therapies against antibioti...
enabling blood-brain barrier permeation and subsequent gene editing of glioblastoma-associated cells [186,187,188]. Lastly, cell-based systematic evolution of ligands by exponential enrichment has also generated novel cell-type specific aptamers (single-stranded DNA or RNA oligonucleotides) that could su...
HOX expression pattern of the HSC/progenitor cell from which the AML arose36; therefore, it is possible that the decreased expression of HOX genes observed in response to DOT1L inhibitor therapy reflects differentiation of the cells rather than a direct cause of DOT1L inhibition on gene ...
MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system,...
The scRNA-seq of gliomas measures gene expression at the single-cell level, thereby uncovering the heterogeneity and evolutionary trajectory of the TME and tumor cells and providing molecular insight into precision therapy. We next briefly discuss what scRNA-seq reveals about the heterogeneity of ...
48 h post electroporation, single cells were sorted into individual wells in 96 well plates using a BD Bioscience BD FACSAria™ Fusion flow cytometer. Twenty single cell-derived clones were analyzed for DOCK8 or Siglec-6 knockdown. MEC1-002 DOCK8 KO (clone #1) and MEC1 Siglec-6 KO ...
A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling. Cell Death Dis. 2, e159 (2011). Article CAS PubMed PubMed Central Google Scholar Wu, L. et al. Tuning cell autophagy by diversifying carbon nanotube surface ...